Chronic toxicity of diphenhydramine hydrochloride and erythromycin thiocyanate to daphnia, Daphnia magna, in a continuous exposure test system
| Autor: | Theresa M. Schreier, Jeanne L. Franz, Jeffry A. Bernardy, Jeffery R. Meinertz |
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| Rok vydání: | 2009 |
| Předmět: |
Diphenhydramine hydrochloride
medicine.drug_class Health Toxicology and Mutagenesis medicine.medical_treatment Daphnia magna Antibiotics Histamine Antagonists Pharmacology Toxicology Daphnia medicine Animals Continuous exposure Toxicity Tests Chronic Chronic toxicity biology General Medicine Erythromycin thiocyanate biology.organism_classification Pollution Survival Analysis Anti-Bacterial Agents Erythromycin Diphenhydramine Environmental chemistry Antihistamine Water Pollutants Chemical |
| Zdroj: | Bulletin of environmental contamination and toxicology. 85(5) |
| ISSN: | 1432-0800 |
| Popis: | Diphenhydramine hydrochloride (DH; Benadryl™, an over-the-counter antihistamine) and erythromycin thiocyanate (ET; a commonly used macrolide antibiotic) are pharmaceutical compounds whose chronic toxicity to Daphnia magna had not been characterized. Continuous exposure to DH concentrations about 5 times greater than the maximum reported environmental concentration of 0.023 μg/L for 21 days or to ET concentrations about 40 times the maximum reported environmental concentration of 6 μg/L for 21 days did not significantly impact D. magna survival and production. In this study the no observable effect concentration for DH was 0.12 μg/L and for ET was 248 μg/L. |
| Databáze: | OpenAIRE |
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