Renal Decapsulation Prevents Intrinsic Renal Compartment Syndrome in Ischemia-Reperfusion–Induced Acute Kidney Injury
| Autor: | Tatiana Salomon, Carlos González, Alejandro Pacheco, Pablo Lillo, Felipe Lillo, Pablo Cruces, Camila Salas, Daniel E. Hurtado |
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| Rok vydání: | 2018 |
| Předmět: |
medicine.medical_specialty
Swine 030232 urology & nephrology Ischemia Urology Renal function Hemodynamics 030204 cardiovascular system & hematology Kidney urologic and male genital diseases Critical Care and Intensive Care Medicine Compartment Syndromes 03 medical and health sciences 0302 clinical medicine medicine Animals Hepatectomy business.industry Acute kidney injury Oxygenation Acute Kidney Injury medicine.disease medicine.anatomical_structure Reperfusion Injury Complication business Perfusion |
| Zdroj: | Critical Care Medicine. 46:216-222 |
| ISSN: | 0090-3493 |
| Popis: | OBJECTIVES Acute kidney injury is a serious complication with unacceptably high mortality that lacks of specific curative treatment. Therapies focusing on the hydraulic behavior have shown promising results in preventing structural and functional renal impairment, but the underlying mechanisms remain understudied. Our goal is to assess the effects of renal decapsulation on regional hemodynamics, oxygenation, and perfusion in an ischemic acute kidney injury experimental model. METHODS In piglets, intra renal pressure, renal tissue oxygen pressure, and dysoxia markers were measured in an ischemia-reperfusion group with intact kidney, an ischemia-reperfusion group where the kidney capsule was removed, and in a sham group. RESULTS Decapsulated kidneys displayed an effective reduction of intra renal pressure, an increment of renal tissue oxygen pressure, and a better performance in the regional delivery, consumption, and extraction of oxygen after reperfusion, resulting in a marked attenuation of acute kidney injury progression due to reduced structural damage and improved renal function. CONCLUSIONS Our results strongly suggest that renal decapsulation prevents the onset of an intrinsic renal compartment syndrome after ischemic acute kidney injury. |
| Databáze: | OpenAIRE |
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