Pulse wave velocity predicts mortality in renal transplant patients
| Autor: | Jens Nürnberger, A Opazo Saez, Andreas Kribben, Oliver Witzke, M Kos, Anna Mitchell |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Adult
Male medicine.medical_specialty Systole Population Medizin lcsh:Medicine Blood Pressure Coronary Disease Pulse Wave Velocity Cohort Studies Heart Rate Predictive Value of Tests Internal medicine Diabetes mellitus medicine Renal Transplantation Humans cardiovascular diseases Longitudinal Studies Mortality education Pulse wave velocity Kidney transplantation Probability education.field_of_study business.industry Research lcsh:R General Medicine Middle Aged medicine.disease Kidney Transplantation Pulse pressure Transplantation Blood pressure Cardiovascular Diseases Cardiology Arterial stiffness cardiovascular system Arterial Stiffness Kidney Failure Chronic Regression Analysis Female business circulatory and respiratory physiology |
| Zdroj: | European Journal of Medical Research European Journal of Medical Research, Vol 15, Iss 10, p 452 (2010) |
| ISSN: | 2047-783X 0949-2321 |
| Popis: | Background Measuring arterial stiffness using pulse wave velocity (PWV) has become an important tool to assess vascular function and cardiovascular mortality. For subject with hypertension, end-stage renal disease and diabetes, PWV has been shown to predict cardiovascular and all-cause mortality. We hypothesize that PWV would also predict mortality in subjects who have undergone kidney transplantation. Methods A cohort of 330 patients with renal transplantation was studied with a mean age at entry 51.4 ± 0.75 years. Mean follow-up was 3.8 years (± 0.7 years); 16 deaths occurred during follow-up. At entry, together with standard clinical and biochemical parameters, PWV was determined from pressure tracing over carotid and femoral arteries. Results With increasing PWV, there was a significant increase in age, systolic blood pressure and pulse pressure. In addition, subjects with higher PWV also exhibited more frequently the presence of coronary heart disease. On the basis of Cox analyses, PWV and systolic blood pressure emerged as predictors of all-cause mortality. Conclusion These results provide evidence that PWV is a strong predictor of all-cause mortality in the population of renal transplant recipients. |
| Databáze: | OpenAIRE |
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