Colour vision and side-effects during treatment with methazolamide
| Autor: | Agneta Mandahl, Ingmar Widengård, Per Törnquist, Per J. Wistrand |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures ATPase Methazolamide Digitalis Color Vision Defects chemistry.chemical_compound Double-Blind Method Internal medicine Carbonic anhydrase medicine Humans Intraocular Pressure Acidosis Retina Cross-Over Studies biology Retinal Carbon Dioxide biology.organism_classification Ophthalmology medicine.anatomical_structure Endocrinology chemistry Enzyme inhibitor biology.protein medicine.symptom medicine.drug |
| Zdroj: | Eye (London, England). 9 |
| ISSN: | 0950-222X |
| Popis: | The retina contains Na + K + -ATPase and carbonic anhydrase (CA), enzymes that regulate ion fluxes across cell membranes of photoreceptors. Since inhibition of retinal Na + K + -ATPase by digitalis impairs colour vision, we wanted to find out whether this also occurs after inhibition of CA. In a double-masked crossover study with placebo, 14 male volunteers were given 50 mg q.i.d. of the CA inhibitor methazolamide for 2 weeks. A disturbance of colour discrimination was observed in 8 of the 14 subjects, in the classification phase of Lanthony New Color Test. The presence of the disturbance was not significantly correlated to the degree of acidosis or to other side-effects. Its mechanism could be interpreted as a specific effect of CA inhibition in the retina (or the visual cortex) calculated to more than 99.9%. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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