Interference with the lower gut-liver axis induces remission of primary sclerosing cholangitis in a patient with ulcerative colitis
| Autor: | Babur Javaid, Jenish Patel, Leila Mebarek, John Ong, Yasseen Al-Naeeb, Carla Swift, Michael F. Bath |
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| Přispěvatelé: | Ong, John [0000-0001-5103-7311], Apollo - University of Cambridge Repository |
| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
IBD Rectum Case Report Disease Gut flora Gastroenterology digestive system Primary sclerosing cholangitis Pathogenesis 03 medical and health sciences Liver disease 0302 clinical medicine Internal medicine medicine Proctitis ulcerative colitis biology business.industry digestive oral and skin physiology primary sclerosing cholangitis medicine.disease biology.organism_classification Ulcerative colitis digestive system diseases medicine.anatomical_structure 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology business |
| Zdroj: | BMJ Open Gastroenterology |
| DOI: | 10.17863/cam.50641 |
| Popis: | The gut–liver axis describes the complex interactions between gut microbiota, the small and large bowel, the immune system and the liver. Current evidence associates abnormalities within the gut–liver axis with liver disease such as primary sclerosing cholangitis (PSC). PSC is believed to be an immune-mediated disease though the exact mechanism of its pathogenesis remains unknown. Here, we report a case of a 66 -year-old woman with treatment-resistant ulcerative colitis and PSC which continued to be active following subtotal colectomy. Interestingly, her PSC achieved full remission after proctectomy for treatment-resistant proctitis in the rectal stump. This case report supports existing hypotheses that PSC is an immune-mediated disease triggered by antigens within the gut. More notably, it suggests the yet unidentified pathogens may be localised to the lower gastrointestinal tract including the rectum. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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