Lipids increase after solitary pancreas transplantation
| Autor: | Robert J. Stratta, Elizabeth Lyden, John P. Leone, Rodney J. Taylor, Judi Erickson, Susan A. Henley, K. Frisbie, Suzanne J. Miller, Jaweed Akhter, Jennifer L. Larsen, Tanaporn Ratanasuwan, Lynn Mack-Shipman |
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| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Blood Pressure Pancreas transplantation Gastroenterology Tacrolimus chemistry.chemical_compound Diabetes mellitus Internal medicine Blood plasma Internal Medicine medicine Humans Triglycerides Advanced and Specialized Nursing Creatinine Type 1 diabetes business.industry Cholesterol Cholesterol HDL medicine.disease Lipids Transplantation Lipoproteins LDL Endocrinology Blood pressure Diabetes Mellitus Type 1 chemistry Cyclosporine lipids (amino acids peptides and proteins) Female sense organs Pancreas Transplantation business Lipoproteins HDL Immunosuppressive Agents Follow-Up Studies |
| Zdroj: | Diabetes care. 22(2) |
| ISSN: | 0149-5992 |
| Popis: | OBJECTIVE: The aims of this study were to determine 1) changes in lipids after solitary pancreas transplantation (SPTX) in patients with type 1 diabetes and 2) factors that influence those changes. RESEARCH DESIGN AND METHODS: Lipids were evaluated prospectively in 24 patients who underwent SPTX. Three were excluded because of early graft failure. The remaining patients (n = 21; 13 men, 8 women) were studied for changes in lipids over time (pre-SPTX, 0-2, 3-6, 7-12, and > 12 months). Glycohemoglobin, serum creatinine, BMI, and medications were also analyzed for their effects on lipid changes. RESULTS: Cholesterol, HDL, and LDL decreased in the immediate postoperative period (0-2 months), whereas triglycerides (TGs) increased (P < 0.05). At 3-6 months, cholesterol, HDL, and TG were higher than before the SPTX, whereas LDL returned to pre-SPTX levels. After 12 months, HDL and TG remained higher than their pre-SPTX levels (P < 0.05). During the study, systolic and diastolic blood pressure increased, renal function decreased, glyco-hemoglobin improved, and weight was unchanged. Changes in cholesterol/HDL ratio, HDL, and TG correlated with changes in prednisone dose (P < 0.05), and changes in TG correlated with changes in creatinine (P < 0.05). The same pattern of lipids occurred in patients prescribed or not prescribed hypolipidemic agents. CONCLUSIONS: Lipids do not improve within the 1st year after SPTX, despite improved glycemic control and blood pressure control, and renal function is worse. These results are in contrast to those reported for combined kidney-pancreas transplantation, where lipids, blood pressure, and renal function improved immediately after transplant. Further studies are needed to determine whether lipids continue to change with time after SPTX. The impact of these changes after SPTX on overall cardiovascular risk is unknown. |
| Databáze: | OpenAIRE |
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