In vivo characterization of neural crest-derived fibro/adipogenic progenitor cells as a likely cellular substrate for craniofacial fibrofatty infiltrating disorders
| Autor: | Fabio M.V. Rossi, Dario R. Lemos, Ben Paylor, Aaron W. Joe |
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| Rok vydání: | 2014 |
| Předmět: |
Population
Biophysics Connective tissue Mice Transgenic PDGFRA Biology Muscle Development Biochemistry Craniofacial Abnormalities Mice Adipocytes medicine Animals Regeneration Craniofacial Progenitor cell Muscle Skeletal education Molecular Biology education.field_of_study Adipogenesis Stem Cells Neural crest Cell Differentiation Cell Biology Cell biology Tissue Degeneration medicine.anatomical_structure Neural Crest Immunology Stem Cell Transplantation |
| Zdroj: | Biochemical and Biophysical Research Communications. 451:148-151 |
| ISSN: | 0006-291X |
| Popis: | The cellular substrate underlying aberrant craniofacial connective tissue accumulation that occurs in disorders such as congenital infiltration of the face (CILF) remain elusive. Here we analyze the in vivo properties of a recently identified population of neural crest-derived CD31-:CD45-:alpha7-:Sca1+:PDGFRa+ fibro/adipogenic progenitors (NCFAPs). In serial transplantation experiments in which NCFAPs were prospectively purified and transplanted into wild type mice, NCFAPs were found to be capable of self-renewal while keeping their adipogenic potential. NCFAPs constitute the main responsive FAP fraction following acute masseter muscle damage, surpassing the number of mesoderm-derived FAPs (MFAPs) during the regenerative response. Lastly, NCFAPs differentiate into adipocytes during muscle regeneration in response to pro-adipogenic systemic cues. Altogether our data indicate that NCFAPs are a population of stem/primitive progenitor cells primarily involved in craniofacial muscle regeneration that can cause tissue degeneration when the damage co-occurs with an obesity inducing diet. |
| Databáze: | OpenAIRE |
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