Investigating the selectivity of potential new inhibitors of dihydrofolate reductase from Yersinia pestis designed by molecular modeling

Autor:	Ricardo Bicca de Alencastro, André S. Pimentel, Felipe Rodrigues de Souza, Pat Forgione, Lucas Miguel Pereira Souza, Tanos C. C. França, Leonardo da Costa Bastos, Teobaldo Cuya
Rok vydání:	2018
Předmět:	Models Molecular Yersinia pestis 030303 biophysics Molecular Conformation Quantitative Structure-Activity Relationship Molecular Dynamics Simulation Plague (disease) Molecular conformation 03 medical and health sciences Structural Biology Dihydrofolate reductase Pandemic Drug Discovery Molecular Biology Genetics 0303 health sciences biology Molecular Structure Hydrogen Bonding General Medicine European population biology.organism_classification Molecular Docking Simulation Tetrahydrofolate Dehydrogenase biology.protein Folic Acid Antagonists Protein Binding
Zdroj:	Journal of biomolecular structuredynamics. 37(5)
ISSN:	1538-0254
Popis:	The three devastating pandemics of plague that humanity faced in the Middle Ages had a great impact on the European population and endorsed the causing agent of plague, the gram-negative bacillus Y...
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b573c189974c7ad4fd41c7cc4e8aa2a1 https://pubmed.ncbi.nlm.nih.gov/29542379 Zobrazit plný text záznamu