Age-Related Memory Impairment Is Associated with Increased zif268 Protein Accumulation and Decreased Rpt6 Phosphorylation

Autor: Brooke N. Dulka, Fred J. Helmstetter, Sydney Trask
Jazyk: angličtina
Rok vydání: 2020
Předmět:
0301 basic medicine
Male
Aging
Proteasome Endopeptidase Complex
Biology
Protein degradation
Amygdala
Catalysis
Article
Inorganic Chemistry
lcsh:Chemistry
memory
03 medical and health sciences
0302 clinical medicine
medicine
Memory impairment
Animals
Cognitive Dysfunction
Fear conditioning
Physical and Theoretical Chemistry
Cognitive decline
Phosphorylation
Prefrontal cortex
Molecular Biology
lcsh:QH301-705.5
Spectroscopy
Early Growth Response Protein 1
Memory Disorders
Recall
Organic Chemistry
Brain
General Medicine
Impaired memory
Rats
Inbred F344
Computer Science Applications
Rats
030104 developmental biology
medicine.anatomical_structure
proteasome
lcsh:Biology (General)
lcsh:QD1-999
Proteolysis
protein degradation
ATPases Associated with Diverse Cellular Activities
Neuroscience
030217 neurology & neurosurgery
immediate early gene
Zdroj: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 5352, p 5352 (2020)
Volume 21
Issue 15
ISSN: 1422-0067
Popis: Aging is associated with cognitive decline, including impairments in the ability to accurately form and recall memories. Some behavioral and brain changes associated with aging are evident as early as middle age, making the understanding of associated neurobiological mechanisms essential to aid in efforts aimed at slowing cognitive decline throughout the lifespan. Here, we found that both 15-month-old and 22-month-old rats showed impaired memory recall following trace fear conditioning. This behavioral deficit was accompanied by increased zif268 protein accumulation relative to 3-month-old animals in the medial prefrontal cortex, the dorsal and ventral hippocampi, the anterior and posterior retrosplenial cortices, the lateral amygdala, and the ventrolateral periaqueductal gray. Elevated zif268 protein levels corresponded with decreases in phosphorylation of the Rpt6 proteasome regulatory subunit, which is indicative of decreased engagement of activity-driven protein degradation. Together, these results identify several brain regions differentially impacted by aging and suggest that the accumulation of proteins associated with memory retrieval, through reduced proteolytic activity, is associated with age-related impairments in memory retention.
Databáze: OpenAIRE
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