Cigarette smoking, proteinuria, and renal function in middle-aged Japanese men from an occupational population
Autor: | Yuichi Yamada, Ryumon Honda, Hitoshi Yokoyama, Masao Ishizaki, Masaru Miyao, Yuka Noborisaka, Masaji Tabata, Minori Nakata |
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Rok vydání: | 2011 |
Předmět: |
Adult
Male medicine.medical_specialty Population Renal function Kidney Kidney Function Tests Japan Cigarette smoking Risk Factors Occupational Exposure Environmental health Internal medicine Odds Ratio Prevalence medicine Humans Elderly people education education.field_of_study Proteinuria business.industry Public health Smoking Public Health Environmental and Occupational Health Regular Article General Medicine Odds ratio Middle Aged Logistic Models medicine.anatomical_structure Endocrinology medicine.symptom business Glomerular Filtration Rate |
Zdroj: | Environmental Health and Preventive Medicine. 17:147-156 |
ISSN: | 1347-4715 1342-078X |
Popis: | To clarify the renal effects of cigarette smoking in a middle-aged occupational population because the effects have previously been demonstrated mainly in community populations that included many elderly people who are thought to be vulnerable to such effects.In 990 middle-aged men recruited from a chemical plant, proteinuria was measured by a dipstick method and the glomerular filtration rate was estimated (eGFR) using a formula proposed by the Japanese Society of Nephrology.Proteinuria was found in 4.6% of the current smokers and 1.5% of the never-smokers. It was found in 4.8% of the subjects having a Brinkman index (BI) of 400-599 and 6.3% of those having a BI of 600 or above. The odds ratio for proteinuria in them was 2.94 (CI: 1.01-8.55) and 3.61 (CI: 1.29-10.1), respectively, adjusting for possible confounders. The mean eGFR was higher in smokers than in nonsmokers throughout middle age up to 64 years. Normal but high eGFR was found in 6.7% of the current heavy smokers and subnormal eGFR in 5.7% of the largest cumulative cigarette consumers in contrast to 3.0% or less of the never-smokers. Proteinuria was found in 13.3% of the subjects showing subnormal eGFR, specifically in 16.7% of the smokers and 8.3% of the nonsmokers.Smoking causes proteinuria in working middle-aged men. Smokers tend to have a high eGFR, but those with subnormal eGFR showed proteinuria most frequently. Whether the high eGFR in smokers will eventually decrease and cause proteinuria remains an important focus for further studies. |
Databáze: | OpenAIRE |
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