CpG island methylation of tumor-related genes in three primary central nervous system lymphomas in immunocompetent patients

Autor: M. Eva Alonso, Dolores Arjona, Jose M. de Campos, Pilar Gonzalez-Gomez, Cinthia Amiñoso, Jesus Lomas, Juan A. Rey, Manuel Gutierrez, Jose L. Sarasa, M. Josefa Bello
Rok vydání: 2003
Předmět:
Male
Cancer Research
Methyltransferase
Lymphoma
Biology
Retinoblastoma Protein
Central Nervous System Neoplasms
Thrombospondin 1
O(6)-Methylguanine-DNA Methyltransferase
Reference Values
Tumor Suppressor Protein p14ARF
Genetics
medicine
Humans
Genes
Tumor Suppressor
Tumor Protein p73
Epigenetics
Promoter Regions
Genetic
neoplasms
Molecular Biology
Cyclin-Dependent Kinase Inhibitor p16
Aged
Glutathione Transferase
Tissue Inhibitor of Metalloproteinase-3
Tumor Suppressor Proteins
Brain
Nuclear Proteins
O-6-methylguanine-DNA methyltransferase
Methylation
DNA Methylation
Middle Aged
Genes
p53
medicine.disease
eye diseases
DNA-Binding Proteins
Isoenzymes
Death-Associated Protein Kinases
Glutathione S-Transferase pi
CpG site
Calcium-Calmodulin-Dependent Protein Kinases
DNA methylation
Cancer research
CpG Islands
Female
Apoptosis Regulatory Proteins
Immunocompetence
Zdroj: Cancer Genetics and Cytogenetics. 142:21-24
ISSN: 0165-4608
Popis: We have determined the promoter CpG island methylation status of O(6)-methylguanine-DNA methyltransferase (MGMT), glutathione-S-transferase P1 (GSTP1), death-associated protein kinase (DAPK), p14(ARF), thrombospondin-1 (THBS1), tissue inhibitor of metalloproteinase-3 gene (TIMP-3), p73, p16(INK4A), RB1, and TP53 genes in three primary central nervous system lymphomas (PCNSL). Five genes (GSTP1, DAPK, TIMP-3, p16(INK4A), and RB1) were hypermethylated in two samples, whereas MGMT, THBS1, and p73 were aberrantly methylated in only one sample. No case presented CpG island methylation for the p14(ARF) and TP53 genes. These findings concur with previous data suggesting a frequent inactivation of p16(INK4A) and very limited involvement of TP53 in PCNSL and also provide insights into the epigenetic molecular involvement of other tumor-related genes in this neoplasm.
Databáze: OpenAIRE
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