Barriers preventing the adoption of comprehensive cancer genomic profiling in the clinic
| Autor: | Susan M. Mockus, Cara Statz, Sara E. Patterson |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Health Knowledge Attitudes Practice medicine.medical_specialty Genomic profiling medicine.medical_treatment Bioinformatics Patient care Pathology and Forensic Medicine Targeted therapy 03 medical and health sciences 0302 clinical medicine Neoplasms Biomarkers Tumor Genetics medicine Humans Genetic Testing Precision Medicine Intensive care medicine Molecular Biology Genome Human business.industry Cancer Sequence Analysis DNA medicine.disease Clinical trial 030104 developmental biology 030220 oncology & carcinogenesis Costs and Cost Analysis Molecular Medicine business Insurance coverage |
| Zdroj: | Expert Review of Molecular Diagnostics. 17:549-555 |
| ISSN: | 1744-8352 1473-7159 |
| Popis: | Comprehensive cancer genomic profiling provides the opportunity to expose the various molecular aberrations potentially driving tumor progression. Consequently, the identity of these genetic drivers can be utilized to match a patient to the most appropriate targeted therapy, thereby increasing the probability of improved clinical outcome. Despite its capability of informing patient care, the adoption of comprehensive cancer genomic profiling in the clinic has not been widespread. The barriers surrounding its universal acceptance are attributed to both physician and patient perspectives. Areas covered: The following report discusses the various obstacles in place, including those related to clinical utility, education, insurance coverage, and clinical trials, which can deter physicians and patients from utilizing genomic profiling for therapeutic decision-making. Expert commentary: The authors review the recent growth and potential of clinical utility studies over the last two years, provide a suggestive framework for educational support, and comment on the use of social media to enhance clinical trial recruitment. |
| Databáze: | OpenAIRE |
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