Health-Related Quality of Life Improvements in Systemic Lupus Erythematosus Derived from a Digital Therapeutic Plus Tele-Health Coaching Intervention: Randomized Controlled Pilot Trial
| Autor: | Raja Malkani, Faiz Khan, Nora Granville, Yash Chathampally |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male medicine.medical_specialty food as medicine digital health Pilot Projects Health Informatics Telehealth lcsh:Computer applications to medicine. Medical informatics Coaching 03 medical and health sciences 0302 clinical medicine systemic lupus erythematosus Quality of life dietary intervention Surveys and Questionnaires Internal medicine Intervention (counseling) Statistical significance medicine Lifestyle medicine Humans Lupus Erythematosus Systemic mobile health 030304 developmental biology 030203 arthritis & rheumatology Original Paper 0303 health sciences digital therapeutic lifestyle medicine Systemic lupus erythematosus business.industry lcsh:Public aspects of medicine autoimmunity lcsh:RA1-1270 Middle Aged medicine.disease Digital health Telemedicine health-related quality of life environmental influences on autoimmunity Quality of Life lcsh:R858-859.7 Female business Internet-Based Intervention |
| Zdroj: | Journal of Medical Internet Research Journal of Medical Internet Research, Vol 22, Iss 10, p e23868 (2020) |
| ISSN: | 1438-8871 |
| Popis: | Background Systemic lupus erythematosus (SLE), a systemic autoimmune disease with no known cure, remains poorly understood and patients suffer from many gaps in care. Recent work has suggested that dietary and other lifestyle factors play an important role in triggering and propagating SLE in some susceptible individuals. However, the magnitude of influence of these triggers, how to identify pertinent triggers in individual patients, and whether removing these triggers confers clinical benefit is unknown. Objective To demonstrate that a digital therapeutic intervention, utilizing a mobile app that allows self-tracking of dietary, environmental, and lifestyle triggers, paired with telehealth coaching, added to usual care, improves quality of life in patients with SLE compared with usual care alone. Methods In this randomized controlled pilot study, adults with SLE were assigned to a 16-week digital therapeutic intervention plus usual care or usual care alone. Primary outcome measures were changes from baseline to 16 weeks on 3 validated health-related quality of life (HRQoL) tools: Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F), Brief Pain Inventory-Short Form (BPI-SF), and Lupus Quality of Life (LupusQoL). Results A total of 50 patients were randomized (23 control, 27 intervention). In per-protocol analysis, the intervention group achieved significantly greater improvement than the control group in 9 of 11 domains: FACIT-F (34% absolute improvement for the intervention group vs –1% for the control group, P Conclusions A digital therapeutic intervention that pairs self-tracking with telehealth coaching to identify and remove dietary, environmental, and lifestyle symptom triggers resulted in statistically significant, clinically meaningful improvements in HRQoL when added to usual care in patients with SLE. Trial Registration ClinicalTrials.gov NCT03426384; https://clinicaltrials.gov/ct2/show/NCT03426384 |
| Databáze: | OpenAIRE |
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