Incidence of Electrographic Seizures in Patients With COVID-19
| Autor: | Brandon L. Waters, Danielle Brigham, Jan Claassen, Michelle Bell, Kiran T. Thakur, Amelia K. Boehme, Andrew J. Michalak |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pediatrics
medicine.medical_specialty Coronavirus disease 2019 (COVID-19) seizure coronavirus Status epilepticus Electroencephalography lcsh:RC346-429 Sepsis 03 medical and health sciences 0302 clinical medicine medicine Ictal 030212 general & internal medicine EEG lcsh:Neurology. Diseases of the nervous system Subclinical infection Coma status epilepticus medicine.diagnostic_test business.industry Incidence (epidemiology) COVID-19 Brief Research Report medicine.disease Neurology Neurology (clinical) medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Frontiers in Neurology Frontiers in Neurology, Vol 12 (2021) |
| ISSN: | 1664-2295 |
| Popis: | Critical illness and sepsis are commonly associated with subclinical seizures. COVID-19 frequently causes severe critical illness, but the incidence of electrographic seizures in patients with COVID-19 has been reported to be low. This retrospective case series assessed the incidence of and risks for electrographic seizures in patients hospitalized with COVID-19 who underwent continuous video electroencephalography monitoring (cvEEG) between March 1st, 2020 and June 30th, 2020. One hundred and twenty-two patients were initially identified who resulted SARS-CoV-2 nasopharyngeal RT-PCR swab positivity with any electroencephalography order placed in the EMR. Seventy-nine patients met study inclusion criteria: age ≥18 years, >1 h of cvEEG monitoring, and positive SARS-CoV-2 nasopharyngeal swab PCR. Six (8%) of the 79 patients suffered electrographic seizures (ES), three of whom suffered non-convulsive status epilepticus. Acute hyperkinetic movements were the most common reason for cvEEG in patients with ES (84%). None of the patients undergoing cvEEG for persistent coma (29% of all patients) had ES. Focal slowing (67 vs. 10%), sporadic interictal epileptiform discharges (EDs; 33 vs. 6%), and periodic/rhythmic EDs (67 vs. 1%) were proportionally more frequent among patients with electrographic seizures than those without these seizures. While 15% of patients without ES had generalized periodic discharges (GPDs) with triphasic morphology on EEG, none of the patients with ES had this pattern. Further study is required to assess the predictive values of these risk factors on electrographic seizure incidence and subsequent outcomes. |
| Databáze: | OpenAIRE |
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