Correlation of Increased Expression of MicroRNA-155 in Bladder Cancer and Prognosis
| Autor: | Hui Wang, Chang-Ping Men |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Clinical Biochemistry Statistics as Topic Urinary Bladder Severity of Illness Index Disease-Free Survival microRNA medicine PTEN Humans Clinical significance Survival rate Survival analysis Aged Retrospective Studies Bladder cancer biology Biochemistry (medical) Middle Aged medicine.disease Prognosis Lymphoma Gene Expression Regulation Neoplastic MicroRNAs Urinary Bladder Neoplasms Hepatocellular carcinoma Multivariate Analysis biology.protein Cancer research Female |
| Zdroj: | Laboratory medicine. 46(2) |
| ISSN: | 1943-7730 |
| Popis: | Objective: To investigate the expression level and clinical significance of microRNA-155 (miR-155) in bladder cancer. Methods: We collected 102 pairs of tissue specimens from patients with primary bladder cancer and adjacent normal bladder specimens between March 2008 and May 2013. Quantitative real-time polymerase chain reaction (QRT-PCR) was performed to detect the expression levels of miR-155. We performed univariate survival analyses using the Kaplan-Meier method and assessed statistical significance between survival curves via the log-rank test. Results: The mean (SD) level of miR-155 expression in tissues with bladder cancer was 13.78 (4.80), which was significantly higher on average than that in adjacent normal bladder tissues (6.14 [2.26], P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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