Phase-based OCT angiography in diagnostic imaging of pediatric retinoblastoma patients: abnormal blood vessels in post-treatment regression patterns
| Autor: | Annette C. Moll, Johannes F. de Boer, Maximilian G. O. Gräfe, Valentina Davidoiu, Oleg Nadiarnykh, Machteld I. Bosscha |
|---|---|
| Přispěvatelé: | Biophotonics and Medical Imaging, LaserLaB - Biophotonics and Microscopy, Amsterdam Neuroscience - Brain Imaging, Amsterdam Reproduction & Development (AR&D), Ophthalmology, ACS - Diabetes & metabolism, APH - Health Behaviors & Chronic Diseases, APH - Quality of Care, CCA - Imaging and biomarkers |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
Nerve fiber layer 01 natural sciences Article 010309 optics 03 medical and health sciences Optical coherence tomography SDG 3 - Good Health and Well-being 0103 physical sciences medicine Medical imaging 030304 developmental biology 0303 health sciences Retina Retinal pigment epithelium medicine.diagnostic_test business.industry Retinoblastoma Magnetic resonance imaging medicine.disease Atomic and Molecular Physics and Optics eye diseases medicine.anatomical_structure Angiography Radiology business Biotechnology |
| Zdroj: | Biomedical Optics Express, 10(5), 2228-2241. The Optical Society Nadiarnykh, O, Davidoiu, V, Grafe, M G O, Bosscha, M, Moll, A C & De Boer, J F 2019, ' Phase-based OCT angiography in diagnostic imaging of pediatric retinoblastoma patients: abnormal blood vessels in post-treatment regression patterns ', Biomedical Optics Express, vol. 10, no. 5, pp. 2228-2241 . https://doi.org/10.1364/BOE.10.002213 Nadiarnykh, O, Davidoiu, V, Gräfe, M G O, Bosscha, M, Moll, A C & de Boer, J F 2019, ' Phase-based OCT angiography in diagnostic imaging of pediatric retinoblastoma patients: Abnormal blood vessels in post-treatment regression patterns ', Biomedical Optics Express, vol. 10, no. 5, pp. 2213-2226 . https://doi.org/10.1364/BOE.10.002213 Biomedical Optics Express, 10(5), 2213-2226. The Optical Society |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/BOE.10.002213 |
| Popis: | Phase-based OCT angiography of retinoblastoma regression patterns with a novel handheld 1050 nm clinical imaging system is demonstrated for the first time in children between 0 and 4 years old under general anesthesia. Angiography is mapped at OCT resolution by flow detection at every pixel with en-face projection from the volume between nerve fiber layer and retinal pigment epithelium. We show a striking difference between blood vasculature of healthy retina, and retinoblastoma regression patterns after chemotherapy, as well as varying complexity of abnormal vasculature in regression patterns types 2, 3, and 4. We demonstrate abnormal, tortuous and prominent vasculature in type 3 regression patterns having the highest risk of tumor recurrences and a lower probability to reduction into flat scars. The ability to visualize 3-D angiography might offer new insights in understanding of retinoblastoma development and its response to therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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