Clonal evolution of chronic lymphocytic leukemia to acute lymphoblastic leukemia
| Autor: | Maria E. Dan, Anwar N. Mohamed, Ricardo Compean, Mitchell R. Smith, Ayad Al-Katib |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Chronic lymphocytic leukemia Biology Lymphocyte Activation Somatic evolution in cancer hemic and lymphatic diseases Acute lymphocytic leukemia Genetics medicine Humans Prolymphocytic leukemia Molecular Biology Chromosome Aberrations Cytogenetics Karyotype Precursor Cell Lymphoblastic Leukemia-Lymphoma medicine.disease Leukemia Lymphocytic Chronic B-Cell Chromosome Banding Clone Cells Leukemia Karyotyping Immunology Clone (B-cell biology) |
| Zdroj: | Cancer Genetics and Cytogenetics. 86:143-146 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/0165-4608(95)00202-2 |
| Popis: | A 38-year-old white man was diagnosed with B-cell chronic lymphocytic/prolymphocytic leukemia (CLL/PLL). The disease was unresponsive to a variety of chemotherapeutic regimes. One year after diagnosis, L3 blasts appeared in peripheral blood associated with more aggressive course. There was no change in the B-cell phenotype at that time, but cytogenetic analysis revealed the appearance of t(8;22)(q24;q11) and -21 superimposed on the original karyotype: 46,XY,+3,der(3)t(3;17)(p11;q12), t(11;14)(q13;q32),-17. These results indicate that the lymphoblastic transformation in our case emerged from the pre-existing B-lymphocytic clone. |
| Databáze: | OpenAIRE |
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