Antiphospholipid antibodies and risk of intrauterine late fetal death
| Autor: | Edoardo Rossi, Luca Bocciolone, Angela Tincani, Michele Tarantini, Carmela Mezzanotte, Cosetta Bianchi, Fabio Parazzini, Plerlulgl Meroni, Armando D'Angelo, Enrico Radici |
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| Rok vydání: | 1994 |
| Předmět: |
Adult
medicine.medical_specialty Adolescent Abortion Sensitivity and Specificity Pregnancy medicine Confidence Intervals Prevalence Humans Risk factor Fetal Death Lupus anticoagulant biology Obstetrics business.industry Case-control study Pregnancy Outcome Obstetrics and Gynecology General Medicine medicine.disease Confidence interval Surgery Case-Control Studies Lupus Coagulation Inhibitor Pregnancy Trimester Second biology.protein Antibodies Antiphospholipid Gestation Female Antibody business |
| Zdroj: | Acta obstetricia et gynecologica Scandinavica. 73(5) |
| ISSN: | 0001-6349 |
| Popis: | Goal of the study was to analyze the relationship between anticardiolipin antibodies, lupus anticoagulant and the risk of intrauterine late fetal death.A case-control study was conducted in a network of general and teaching hospitals in northern Italy. Cases studied were 99 women (median age 27 years), without clinical evidence of systemic lupus erythematosus or other immunological disorders who had an 'unexplained' intrauterine fetal death at or after the 20 weeks of gestation. The control subjects were 85 women (median age 28 years) who gave birth at term (37 weeks gestation) to healthy infants on randomly selected days at the same hospitals where cases had been identified.The presence of lupus anticoagulant was detected in four of the 99 cases (4%, 95% confidence interval 2%-15%) and none of the 85 controls. A total of 10 out of the 89 cases (11%, 95 confidence interval 6%-23%), but none of the 79 controls for whom anticardiolipin antibodies value was available had elevated anticardiolipin antibodies; this difference was statistically significant (chi 2(1) = 9.38, p0.01). |
| Databáze: | OpenAIRE |
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