Correlation of enthesitis indices with disease activity and function in axial and peripheral spondyloarthritis : a cross-sectional study comparing MASES, SPARCC and LEI
| Autor: | Charles Lubianca Kohem, Felipe Borges de Oliveira, Sandra Lúcia Euzébio Ribeiro, Andrese Aline Gasparin, Ricardo Machado Xavier, Bruno Meira Guerra, Jady Wroblewski Xavier, Aline Castello Branco Mancuso, Ana Paula Beckhauser de Campos, Penelope Esther Palominos, Percival D. Sampaio-Barros, Carla Saldanha |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
lcsh:Immunologic diseases. Allergy
musculoskeletal diseases Adult Male medicine.medical_specialty lcsh:Diseases of the musculoskeletal system Cross-sectional study Enthesopathy Severity of Illness Index Espondilartrite Statistics Nonparametric Disease activity Correlation Young Adult Rheumatology Quality of life Internal medicine Spondylarthritis Spondyloarthritis medicine Prevalence Enthesitis Humans Spondylitis Ankylosing Function BASDAI Aged Aged 80 and over Receiver operating characteristic Índice de gravidade de doença business.industry Arthritis Psoriatic Middle Aged Cross-Sectional Studies ROC Curve Estudos transversais Female lcsh:RC925-935 medicine.symptom lcsh:RC581-607 business BASFI Brazil |
| Zdroj: | Repositório Institucional da UFRGS Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS Advances in Rheumatology, Vol 59, Iss 1, Pp 1-9 (2019) |
| Popis: | Background The presence of enthesitis is associated with higher disease activity, more disability and incapacity to work and a poorer quality of life in spondyloarthritis (SpA). There is currently no consensus on which clinical score should be used to assess enthesitis in SpA. The objective of the present work was to compare the correlation of three enthesitis indices (MASES, SPARCC and LEI) with measures of disease activity and function in a heterogeneous population of patients with axial and peripheral SpA. Methods A cross-sectional study was conducted in three Brazilian public university hospitals; patients fulfilling ASAS classification criteria for peripheral or axial SpA were recruited and measures of disease activity and function were collected and correlated to three enthesitis indices: MASES, SPARCC and LEI using Spearman’s Correlation index. ROC curves were used to determine if the the enthesitis indices were useful to discriminate patients with active disease from those with inactive disease. Results Two hundred four patients were included, 71.1% (N = 145) fulfilled ASAS criteria for axial SpA and 28.9% (N = 59) for peripheral SpA. In axial SpA, MASES performed better than LEI (p = 0.018) and equal to SPARCC (p = 0.212) regarding correlation with disease activity (BASDAI) and function (BASFI). In peripheral SpA, only MASES had a weak but statistical significant correlation with DAS28-ESR (rs 0.310 p = 0.05) and MASES had better correlation with functional measures (HAQ) than SPARCC (p = 0.034). Conclusion In this sample composed of SpA patients with high coexistence of axial and peripheral features, MASES showed statistical significant correlation with measures of disease activity and function in both axial and peripheral SpA. |
| Databáze: | OpenAIRE |
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