Combined effect of cisplatin and lymphokine-activated killer cells on A549 cells of non-small cell lung cancer
Autor: | G. K. Gerasimova, O. S. Zhukova, M. V. Kiselevskii, I. Zh. Shubina |
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Rok vydání: | 2007 |
Předmět: |
Cytotoxicity
Immunologic Lung Neoplasms Antineoplastic Agents chemical and pharmacologic phenomena Immunotherapy Adoptive General Biochemistry Genetics and Molecular Biology Natural killer cell NK-92 Antigen Carcinoma Non-Small-Cell Lung Cell Line Tumor medicine Humans Cytotoxic T cell Killer Cells Lymphokine-Activated A549 cell Lymphokine-activated killer cell Chemistry General Medicine Natural killer T cell Combined Modality Therapy medicine.anatomical_structure Immunology Interleukin 12 Cancer research Interleukin-2 Cisplatin |
Zdroj: | Bulletin of Experimental Biology and Medicine. 144:231-234 |
ISSN: | 1573-8221 0007-4888 |
DOI: | 10.1007/s10517-007-0297-2 |
Popis: | We studied the ability of lymphokine-activated killer cells to lyse A549 human non-small cell lung cancer cells after preincubation with cisplatin. Lymphokine-activated killer cells obtained after incubation of human blood lymphocytes with interleukin-2 were characterized by high expression of natural killer cell antigens and activation molecules. Lymphokine-activated killer cells produced potent cytotoxic effect on intact A549 cells and lysed tumor cells survived after treatment with cisplatin in concentrations of IC50 and IC30. Cisplatin in noncytotoxic concentrations did not increase lytic activity of lymphokine-activated killer cells. |
Databáze: | OpenAIRE |
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