Reproducibility of cerebral tissue oxygen saturation measurements by near-infrared spectroscopy in newborn infants
Autor: | Carmen Jenny, Hans Ulrich Bucher, Ivo Trajkovic, Martin Wolf, Jean-Claude Fauchère, Martin Biallas |
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Přispěvatelé: | University of Zurich, Wolf, M |
Rok vydání: | 2011 |
Předmět: |
Male
medicine.medical_specialty Materials science Biomedical Engineering 2204 Biomedical Engineering 610 Medicine & health 3107 Atomic and Molecular Physics and Optics Statistics Nonparametric Hypoxemia Biomaterials medicine Humans Oximetry Neonatology Hypoxia Brain Oxygen saturation (medicine) Brain Chemistry Reproducibility Spectroscopy Near-Infrared 2502 Biomaterials Near-infrared spectroscopy Infant Newborn Brain Reproducibility of Results 2504 Electronic Optical and Magnetic Materials Gestational age Oxygenation 10027 Clinic for Neonatology Atomic and Molecular Physics and Optics Electronic Optical and Magnetic Materials Surgery Oxygen Female Cerebral tissue medicine.symptom Algorithms Biomedical engineering |
Zdroj: | Journal of Biomedical Optics. 16:097004 |
ISSN: | 1083-3668 |
DOI: | 10.1117/1.3622756 |
Popis: | Early detection of cerebral hypoxemia is an important aim in neonatology. A relevant parameter to assess brain oxygenation may be the cerebral tissue oxygen saturation (StO(2)) measured by near-infrared spectroscopy (NIRS). So far the reproducibility of StO(2) measurements was too low for clinical application, probably due to inhomogeneities. The aim of this study was to test a novel sensor geometry which reduces the influence of inhomogeneities. Thirty clinically stable newborn infants, with a gestational age of median 33.9 (range 26.9 to 41.9) weeks, birth weight of 2220 (820 to 4230) g, postnatal age of 5 (1 to 71) days were studied. At least four StO(2) measurements of 1 min duration were carried out using NIRS on the lateral head. The sensor was repositioned between measurements. Reproducibility was calculated by a linear mixed effects model. The mean StO(2) was 79.99 ± 4.47% with a reproducibility of 2.76% and a between-infant variability of 4.20%. Thus, the error of measurement only accounts for 30.1% of the variability. The novel sensor geometry leads to considerably more precise measurements compared to previous studies with, e.g., ∼5% reproducibility for the NIRO 300. The novel StO(2) values hence have a higher clinical relevance. |
Databáze: | OpenAIRE |
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