Effects of β-carotene intake on the risk of fracture: A Bayesian meta-analysis
Autor: | Shuman Yang, Ann M Vuong, Tesfaye Getachew Charkos, Yawen Liu, Kemal Sherefa Oumer |
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Rok vydání: | 2020 |
Předmět: |
Male
China medicine.medical_specialty endocrine system lcsh:Diseases of the musculoskeletal system 030209 endocrinology & metabolism β-Carotene Cochrane Library Bayesian law.invention 03 medical and health sciences 0302 clinical medicine Rheumatology Randomized controlled trial law Internal medicine Epidemiology medicine Credible interval Humans Orthopedics and Sports Medicine 030212 general & internal medicine Hip fracture Hip Fractures business.industry Bayes Theorem Middle Aged beta Carotene medicine.disease Europe Meta-analysis Fracture Relative risk Osteoporosis Female lcsh:RC925-935 business Vitamin a Research Article Cohort study |
Zdroj: | BMC Musculoskeletal Disorders, Vol 21, Iss 1, Pp 1-9 (2020) BMC Musculoskeletal Disorders |
Popis: | Background Epidemiological studies examining the association between β-carotene intake and risk of fracture have reported inconsistent findings. We conducted a meta-analysis to investigate the association between β-carotene intake and risk of fracture. Methods We systematically searched PubMed, EMBASE and Cochrane library databases for relevant articles that were published until December 2019. We also identified studies from reference lists of articles identified from the clinical databases. The frequentist and Bayesian random-effects model was used to synthesize data. Results Nine studies with a total of 190,545 men and women, with an average age of 59.8 years, were included in this meta-analysis. For β-carotene intake (1.76–14.30 mg/day), the pooled risk ratio (RR) of any fracture was 0.67 (95% Credible Interval (CrI): 0.51–0.82; heterogeneity: P = 0.66, I2 = 0.00%) and 0.63 (95%CrI: 0.44–0. 82) for hip fracture. By study design, the pooled RRs were 0.55 (95% CrI: 0.14–0.96) for case-control studies and 0.82 (95% CrI: 0.58–0.99) for cohort studies. By geographic region, the pooled RRs were 0.58 (95% CrI: 0.28–0.89), 0.86 (95% CrI: 0.35–0.1.37), and 0.91(95% CrI: 0.75–1.00) for studies conducted in China, the United States, and Europe, respectively. By sex, the pooled RRs were 0.88 (95% CrI: 0.73–0.99) for males and 0.76 (95% CrI, 0.44–1.07) for females. There was a 95% probability that β-carotene intake reduces risk of hip fracture and any type of fracture by more than 20%. Conclusions The present meta-analysis suggests that β-carotene intake was inversely associated with fracture risk, which was consistently observed for case-control and cohort studies. Randomized controlled trials are warranted to confirm this relationship. |
Databáze: | OpenAIRE |
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