Pediatric brain tumors in Nigeria: clinical profile, management strategies, and outcome
| Autor: | E O Uche, Matthew T Shokunbi, IA Lagunju, S. D. Amanor-Boadu, Effiong E. Akang, Adefolarin O. Malomo |
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| Rok vydání: | 2012 |
| Předmět: |
Male
medicine.medical_specialty Pediatrics Adolescent Brain tumor Nigeria Astrocytoma Neurosurgical Procedures Tertiary Care Centers Neuroimaging Seizures medicine Humans Psychiatry Cerebellar Neoplasms Child Survival rate Developing Countries Retrospective Studies Medulloblastoma Reflex Abnormal business.industry Brain Neoplasms Headache Infant Retrospective cohort study General Medicine medicine.disease Prognosis Hydrocephalus Survival Rate Child Preschool Pediatrics Perinatology and Child Health Female Radiotherapy Adjuvant Neurology (clinical) Neurosurgery business |
| Zdroj: | Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 29(7) |
| ISSN: | 1433-0350 |
| Popis: | Although modern neuroimaging has facilitated early care of brain tumors in children worldwide, there are, however, few published reports on clinical profile, treatment, and outcome of brain tumors in children from our subregion.We aimed to retrospectively study the clinical profile and outcome of pediatric brain tumors in a tertiary referral center from a developing country.Forty pediatric patients with histologically verified brain tumors managed by the authors over a 13-year period (May 1994-April 2006) were studied. Patients' data from clinical, radiological, and pathology records were analyzed using the statistical package for social sciences version 16.The mean age was 9.75 years (range 1-15 years). Twenty-two males, 18 females. Common presenting symptoms were headaches (23 patients, 57.5%) and seizures (15 patients, 37.5%). Hyperreflexia (72.5%) and focal motor deficits (62.5%) were the most common neurologic signs. The mean interval from onset of symptoms to neurosurgical diagnosis was 13.4 months (95% CI). All patients had tumor resection, while 11 (27.5%) patients received adjuvant radiotherapy. Hydrocephalus occurred in 19 (47.5%) patients and was associated with early presentation (X2 = 10.65, p 0.01). Low-grade astrocytoma (25%) and medulloblastoma (25%) were the most common tumors. Survival at 1 and 5 years were 56 and 47%, respectively.Focal motor signs and elevated intracranial pressure are the salient presenting features of brain tumors in children seen in Nigeria. Those of them with hydrocephalus are likely to present early. The outcome for pediatric brain tumors remains poor. |
| Databáze: | OpenAIRE |
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