Low-dose antacids or cimetidine for duodenal ulcer?
| Autor: | Arnold Berstad, Kåre R. Vetvik, Nils Hovdenak, Erik Aubert, O. J. Lange, Per G. Farup, Asbjørn Stallemo, Olav Dahlberg, Magnus Melsom, Ragnar Weberg, Jan Dybdahl, Erik Ellekjær |
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| Předmět: |
Male
medicine.medical_specialty Time Factors medicine.medical_treatment Gastroenterology Random Allocation Double-Blind Method Healing rate Antacid Internal medicine Multicenter trial medicine Humans Multicenter Studies as Topic Cimetidine Wound Healing Hepatology business.industry Low dose Confidence interval Duodenal ulcer Regimen Anesthesia Duodenal Ulcer Female Antacids business medicine.drug |
| Zdroj: | Europe PubMed Central Scopus-Elsevier |
| Popis: | In a double-blind, randomized, multicenter trial 150 consecutive outpatients with endoscopically verified duodenal ulcer were treated with either a low-dose antacid regimen (1 tablet q.i.d.; acid-neutralizing capacity, 120 mmol/day), or cimetidine (800 mg nocte). After 4 wk of treatment control gastroscopy showed ulcer healing in 54 of 76 patients (71.1%) in the antacid group, as compared with 58 of 74 patients (78.4%) in the cimetidine-treated group. The difference in healing rate of 7.3% (95% confidence interval, -6.5% to +21.1%) was not statistically significant. The symptomatic effect, measured as number of days and nights with ulcer pain, was also quite similar in the two treatment groups. However, the number of days with pain was significantly lower in the first week of treatment in the antacid group (p less than 0.01). Thus, the efficacy of a low-dose antacid tablet regimen approximated that of cimetidine (800 mg nocte) in the treatment of duodenal ulcer patients. |
| Databáze: | OpenAIRE |
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