Anti-glomerular Basement Membrane Glomerulonephritis During the First Trimester of Pregnancy

Autor: Kunihiro Yamagata, Naoki Morito, Takashi Tawara, Mayumi Takahashi-Kobayashi, Kei Nagai, Hiromi Hamada, Shuzo Kaneko, Joichi Usui, Ryoya Tsunoda, Ryota Ishii, Hirayasu Kai, Chie Saito, Akiko Fujita
Jazyk: angličtina
Rok vydání: 2020
Předmět:
HLA-DRB1*1502:01
Adult
medicine.medical_specialty
medicine.medical_treatment
Kidney Glomerulus
Renal function
1st trimester of pregnancy
Case Report
030204 cardiovascular system & hematology
Gastroenterology
anti-glomerular basement membrane glomerulonephritis (anti-GBM GN)
Antibodies
Antineutrophil Cytoplasmic
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Glomerulonephritis
Pregnancy
Internal medicine
Internal Medicine
medicine
Humans
Autoantibodies
Peroxidase
Fetus
Creatinine
rapid progressive glomerulonephritis (RPGN)
plasma exchange (PE)
business.industry
Glomerular basement membrane
General Medicine
medicine.disease
Pregnancy Trimester
First
medicine.anatomical_structure
chemistry
Prednisolone
030211 gastroenterology & hepatology
Female
Hemodialysis
business
medicine.drug
Zdroj: Internal Medicine
ISSN: 1349-7235
0918-2918
Popis: A 28-year-old woman was admitted during the eighth week of her pregnancy because her clinical course was consistent with rapid progressive glomerulonephritis (RPGN). Anti-glomerular basement membrane antibody (anti-GBM Ab) and myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) were positive, and the anti-GBM Ab titer being extremely high. She was treated with hemodialysis, plasma exchange and prednisolone. She survived the illness; however, neither the fetus nor her kidney function could be rescued. She had human leukocyte antigen (HLA)-DRB1*1502:01, which differs from the DRB1*1501 associated with anti-GBM GN. When patients have particular symptoms, we should check the urine and serum creatinine to exclude RPGN, even in cases of pregnancy.
Databáze: OpenAIRE
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