Evaluation of the Monoclonal Antibody Antithyroperoxidase MoAb47 in the Diagnostic Decision of Cold Thyroid Nodules by Fine-Needle Aspiration
| Autor: | Pluot M, D. Menzies, M. Patey, M.J. Faroux, S Theobald |
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| Rok vydání: | 1997 |
| Předmět: |
Thyroid nodules
Pathology medicine.medical_specialty medicine.drug_class Cytodiagnosis Immunocytochemistry Monoclonal antibody Iodide Peroxidase Pathology and Forensic Medicine Thyroid peroxidase Cytology Adenocarcinoma Follicular medicine Humans Thyroid Neoplasms Thyroid Nodule skin and connective tissue diseases biology medicine.diagnostic_test business.industry Biopsy Needle Antibodies Monoclonal Cell Biology medicine.disease Immunohistochemistry Carcinoma Papillary body regions surgical procedures operative Fine-needle aspiration Evaluation Studies as Topic Monoclonal biology.protein Radiology business |
| Zdroj: | Pathology - Research and Practice. 193:705-712 |
| ISSN: | 0344-0338 |
| DOI: | 10.1016/s0344-0338(97)80030-1 |
| Popis: | Fine needle aspiration (FNA) of cold thyroid nodules has become the first line diagnostic decision for electing which patients need surgery. In order to improve FNA accuracy, the monoclonal antithyroperoxidase (TPO) antibody (MoAb47) was tested. A total of 554 patients were included in this study and among them, 208 were referred to surgery. The results of FNA compared to the final histological diagnosis revealed a sensitivity and a specificity of 94 and 55% respectively, while the sensitivity and specificity of TPO immunodetection on the same cases reached 98 and 83% respectively. By combining the two methods, the 3 false-negative of FNA and 60% of suspicious cytology corresponding to histological benign lesions were correctly identified by immunocytochemistry. With better results than FNA alone, TPO immunodetection with MoAb47 represents a useful adjunct to conventional cytology for selecting patients for surgery. |
| Databáze: | OpenAIRE |
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