Protective effects of dexmedetomidine and remote ischemic preconditioning on renal ischemia reperfusion injury in rats
| Autor: | Belgin Ünal, Mert Akan, Cansu Balci, Sevda Özkardeşler, Nilay Boztaş, Mustafa Ensari Güneli, Bekir Ugur Ergur |
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| Rok vydání: | 2017 |
| Předmět: |
Male
medicine.medical_treatment Ischemia 030204 cardiovascular system & hematology Kidney Protective Agents 030226 pharmacology & pharmacy 03 medical and health sciences 0302 clinical medicine Laparotomy Occlusion medicine Animals Dexmedetomidine Rats Wistar Ischemic Preconditioning Renal ischemia business.industry medicine.disease Rats Anesthesiology and Pain Medicine medicine.anatomical_structure Anesthesia Reperfusion Injury Emergency Medicine Ischemic preconditioning Surgery business Reperfusion injury medicine.drug |
| Zdroj: | Ulusal travma ve acil cerrahi dergisi = Turkish journal of traumaemergency surgery : TJTES. 23(4) |
| ISSN: | 1306-696X |
| Popis: | BACKGROUND The aim of this study was to evaluate the effects of remote ischemic preconditioning (RIPC) and dexmedetomidine as pharmacological conditioning in a rat renal ischemia/reperfusion (IR) injury model. METHODS Total of 28 male Wistar Albino rats weighing 250 to 300 g were divided into 4 equal groups. Group I (Sham; n=7): Laparotomy and renal pedicle dissection were performed, and the rats were observed under anesthesia without any intervention. Group II (IR; n=7): Following laparotomy and 45 minutes of left renal pedicle occlusion, 4 hours of reperfusion was performed. Group III (IR+D; n=7): Following laparotomy and ischemia, dexmedetomidine was administrated intraperitoneally (100 µg/kg) at fifth minute of reperfusion. Group IV (RIPC+IR; n=7): Under anesthesia, 3 cycles of ischemic preconditioning were applied to the left hind leg, and after 5 minutes, renal IR was performed. All rats were sacrificed after the left kidney was processed for conventional histomorphology. RESULTS Total histomorphological renal injury score was significantly lower in the Sham group compared with the other groups (p |
| Databáze: | OpenAIRE |
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