Mathematical model to predict the need for neodymium: YAG capsulotomy based on posterior capsule opacification rate
| Autor: | Jared M. Emery, Mark E. Munsell, Donald S. Clark |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Adult
Male medicine.medical_specialty Time Factors medicine.medical_treatment Lens Capsule Crystalline chemistry.chemical_element Ricin Placebo Neodymium Placebo group Cataract Clinical study Cohort Studies Lens Implantation Intraocular Ophthalmology Lens Crystalline medicine Humans Posterior capsule opacification Aged Treated group Phacoemulsification business.industry Immunotoxins Antibodies Monoclonal Epithelial Cells Middle Aged Models Theoretical eye diseases Sensory Systems Surgery chemistry Capsulotomy Female Laser Therapy business |
| Zdroj: | Journal of cataract and refractive surgery. 24(12) |
| ISSN: | 0886-3350 |
| Popis: | To evaluate a model to project the estimated time required before patients having primary phacoemulsification require neodymium:YAG (Nd:YAG) laser capsulotomy.Eleven private practices in the United States.Projections of time to capsulotomy were based on assessment of the early development of posterior capsule opacification (PCO) over time. The PCO data were collected during a clinical study to evaluate MDX-RA, an investigational immunotoxin designed to limit epithelial cell growth, preventing postsurgical PCO. From the PCO data, the estimated time to Nd:YAG capsulotomy in a placebo-treated group was compared with the actual time to capsulotomy in a cohort of patients from general practice who had had phacoemulsification.By 6 months, the mean Opacification Index in the MDX-RA group was significantly lower than that in the placebo group (P.05) and it remained significantly lower at 12 (P.001), 18 (P.001), and 24 (P.016) months. The rate of PCO in the MDX-RA group was approximately 6 times lower than that in the placebo group (P.0004). Fifty-seven percent in the placebo group and 4% in the MDX-RA group were projected to require an Nd:YAG capsulotomy within 3 years of primary cataract surgery. Projected values for the placebo group were similar to actual values observed in the population-based cohort.This technique could be used to predict the need for Nd:YAG capsulotomy using early measurements of PCO. |
| Databáze: | OpenAIRE |
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