Multiple Non-coding ANRIL Transcripts Are Associated with Risk of Coronary Artery Disease: a Promising Circulating Biomarker
Autor: | Dongfei Wang, Rui Xu, Jialan Lv, Xiaogang Guo, Xingxiang Wang, Yun-Peng Jin, Yang Dong, Xiang Yin, Zhicheng Pan, Juan Fang, Xudong Xie, Jianpeng Sheng |
---|---|
Rok vydání: | 2020 |
Předmět: |
Male
0301 basic medicine Oncology medicine.medical_specialty Pharmaceutical Science CAD Coronary Artery Disease 030204 cardiovascular system & hematology Coronary Angiography Risk Assessment Coronary artery disease 03 medical and health sciences 0302 clinical medicine Predictive Value of Tests Risk Factors Internal medicine Genetics Humans Medicine cardiovascular diseases Genetics (clinical) Aged business.industry Incidence (epidemiology) Reproducibility of Results Middle Aged Prognosis medicine.disease Peripheral blood Human genetics Circulating biomarkers 030104 developmental biology Case-Control Studies Molecular Medicine Biomarker (medicine) Female RNA Long Noncoding Cardiology and Cardiovascular Medicine business Biomarkers Mace |
Zdroj: | Journal of Cardiovascular Translational Research. 14:229-237 |
ISSN: | 1937-5395 1937-5387 |
Popis: | Multiple ANRIL transcriptional isoforms, such as lncANRIL and circANRIL have been identified. We sought to explore their diagnostic value in patients with coronary artery disease (CAD). First, we selected six target ANRIL isoforms and measured their expression in CAD patients and controls in the peripheral blood. Their diagnostic values were evaluated. circANRIL(exon14-4) was identified as the best potential biomarker. Afterwards, we validated its diagnostic value and evaluated its prognostic value in a larger clinical cohort. Among six tested ANRILs, lncANRIL(exon1) and lncANRIL(exon4-6) in the CAD patients were significantly increased, while circANRIL(exon14-4) was downregulated. circANRIL(exon14-4) had the highest diagnostic value among the three isoforms. The combination of circANRIL(exon14-4) and other factors resulted in a more accurate differentiation of CAD patients. Moreover, lower expression of circANRIL(exon14-4) was associated with higher incidence of MACE. circANRIL(exon14-4) is closely associated with CAD risk and severity, which provides a promising circulating biomarker for CAD diagnosis and prognosis. |
Databáze: | OpenAIRE |
Externí odkaz: |