A linear mass concentration detector for solvent gradient polymer separations
| Autor: | Eric Pearce, Emily H. Mordan, James H. Wade, Ryan C. Bailey, David M. Meunier |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
chemistry.chemical_classification
Materials science 010401 analytical chemistry Detector Size-exclusion chromatography Analytical chemistry 02 engineering and technology Polymer equipment and supplies 021001 nanoscience & nanotechnology 01 natural sciences Biochemistry Light scattering 0104 chemical sciences Analytical Chemistry chemistry.chemical_compound chemistry Chromatography detector Electrochemistry Environmental Chemistry Polystyrene Polymer blend 0210 nano-technology Refractive index Spectroscopy |
| Zdroj: | The Analyst. 145(13) |
| ISSN: | 1364-5528 |
| Popis: | Characterization of copolymers requires the measurement of two distributions—molecular weight (MW) and chemical composition (CC). Molecular weight distributions (MWD) are traditionally determined using size exclusion chromatography (SEC) run under isocratic solvent conditions. Chemical composition distributions (CCD) are often determined using liquid adsorption chromatography (LC) with solvent gradients. The use of solvent gradients, however, often limits options of compatible detectors. A gradient compatible, universal linear mass concentration detector is a longstanding unmet need. Many industrially-relevant polymers lack chromophores or other discriminating moieties requiring detectors with a universal response. Differential refractive index (dRI) is incompatible with gradient elution due to its small dynamic range. Charged aerosol detectors (CAD) and evaporative light scattering detectors (ELSD) are probably the most promising options for gradient elution detection, but both suffer from a nonlinear mass concentration response. Silicon photonic microring resonators are optical sensors that are responsive to changes in the local refractive index (RI). The substantial dynamic range of this technology makes it attractive for refractive index-based detection during solvent gradient elution. Previously, the microring resonator platform was used as a SEC detector to characterize the MWD of broadly dispersed polystyrene (PS) standards. In this study, we demonstrate the gradient compatibility of the microring resonator platform for polymer detection by quantifying the CCD of polymer blend components. Control experiments were run with UV and ELSD detection, highlighting the uniqueness of the platform as a linear mass concentration detector with a universal detector response. |
| Databáze: | OpenAIRE |
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