A prospective comparison of two endogenous creatinine clearance testing methods in hospitalized hypertensive gravid women
| Autor: | John F. Huddleston, William Huggins, Charles E. Flowers, Gail S. Williams |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Time Factors Pregnancy Trimester Third Posture Pregnancy Complications Cardiovascular Urology Drinking Renal function Endogeny Third trimester Kidney Pregnancy medicine Creatinine clearance test Humans Obesity Prospective Studies Prospective cohort study business.industry Obstetrics and Gynecology Kidney metabolism Reproducibility of Results medicine.disease Surgery Creatinine Hypertension Regression Analysis Female business Urine collection |
| Zdroj: | American journal of obstetrics and gynecology. 169(3) |
| ISSN: | 0002-9378 |
| Popis: | Although 24-hour endogenous creatinine clearance testing is common in pregnancies complicated by hypertension, inaccuracies limit its usefulness. We controlled the conditions under which 4-hour endogenous creatinine clearance testing was performed and compared the results with outcomes of 24-hour tests from the same patients.In 83 women hospitalized with mild hypertension in the third trimester, we measured endogenous creatinine clearance with a 4-hour urine collection during lateral recumbency and supervised oral hydration. This test was paired with a 24-hour test performed immediately thereafter. No restrictions or recommendations regarding ambulation or oral intake were imposed for the 24-hour test.The 4-hour endogenous creatinine clearance value exceeded the 24-hour value in 133 of the 136 paired comparisons (p0.0001). Results of the tests from only the 29 patients with multiple paired tests showed more similarity (p0.005) among the 4-hour than among the 24-hour clearances.The 4-hour endogenous creatinine clearance test, as described, provides a higher and less variable estimate of renal function in hypertensive pregnant women than does the 24-hour test. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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