Patients with longstanding primary antiphospholipid syndrome: retrospective analysis of organ damage and mortality
| Autor: | Micol Frassi, Rossella Reggia, Mara Taraborelli, Marco Taglietti, Angela Tincani, Francesca Dall'Ara, Franco Franceschini, Laura Andreoli |
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| Rok vydání: | 2014 |
| Předmět: |
Primary antiphospholipid syndrome
Adult Male medicine.medical_specialty mortality organ damage outcome Disease Systemic autoimmune disease Rheumatology Internal medicine medicine Retrospective analysis Humans In patient Connective Tissue Diseases Aged Retrospective Studies business.industry Mean age Middle Aged Antiphospholipid Syndrome Surgery Organ damage Female business |
| Zdroj: | Lupus. 23:1255-1258 |
| ISSN: | 1477-0962 0961-2033 |
| Popis: | Objective To assess the prevalence of disease- and therapy-related complications and of the organ damage after a follow-up of 15 years or more in patients with primary antiphospholipid syndrome (PAPS). Methods Medical records of patients prospectively followed in our centre for at least 15 years were retrospectively reviewed. Results Thirty-five Caucasian patients (33 female, two male) with diagnosis of PAPS followed from 1984 to 2013 with a mean age at onset of 32 years (SD 8.17) and a median follow-up of 20.5 years (range 15–30) were included. The occurrence of systemic autoimmune disease was observed in 14% of patients. Haemorrhagic, infective and neoplastic events were recorded in 34%, 6% and 9% respectively. Organ damage was present in 20% of patients at the end of the follow-up (17% neurological and 3% renal) and was significantly associated with the occurrence of thrombotic events ( p: 0.027), particularly arterial ( p Conclusion During long-term follow-up of PAPS systemic autoimmunity is not unexpected. Organ damage progresses in a significant proportion of patients especially if they have suffered previous arterial events. Our study clearly shows the possible evolution of the disease and of organ damage, suggesting that optimal therapy and optimal prophylaxis of each PAPS patient should be carefully identified and strictly applied. |
| Databáze: | OpenAIRE |
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