High-water-absorbing calcium alginate fibrous scaffold fabricated by microfluidic spinning for use in chronic wound dressings
| Autor: | Jie Cai, Peifeng Liu, Hui Yu, Dongdong Ye, Xiaojing Wang, Yongtang Jia, Yulu Tan, Xiaojing Chen |
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| Rok vydání: | 2018 |
| Předmět: |
Chronic wound
Scaffold Materials science Calcium alginate integumentary system General Chemical Engineering Microfluidics 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Biocompatible material 01 natural sciences Silver nanoparticle 0104 chemical sciences chemistry.chemical_compound chemistry medicine medicine.symptom 0210 nano-technology Spinning Biomedical engineering |
| Zdroj: | RSC Advances. 8:39463-39469 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c8ra06922k |
| Popis: | More and more water-absorbing wound dressings have been studied since moist wound-healing treatment can effectively promote the healing of wounds. In this work, we introduce a novel method to produce improved wound dressings with high-water-absorbance. A high-water-absorbing calcium alginate (Ca-Alg) fibrous scaffold was fabricated simply by microfluidic spinning and centrifugal reprocessing. The structure and physical properties of the scaffold were characterized, and its water-absorbing, cytotoxicity properties and other applicability to wound dressings were comprehensively evaluated. Our results indicate that this material possesses high water-absorbing properties, is biocompatible, and has a 3D structure that mimics the extracellular matrix, while Ca-Alg fibers loaded with silver nanoparticles (AgNPs) exhibit broad-spectrum antibacterial activities; these properties meet the requirements for promoting the healing of chronic wounds and are widely applicable to wound dressings. |
| Databáze: | OpenAIRE |
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