The Impact of Newer Treatment Modalities on Survival in Patients With Hepatocellular Carcinoma
| Autor: | Tatsuki Ichikawa, Masumi Fujimoto, Naota Taura, Hidetaka Shibata, Katsumi Eguchi, Yasuhide Motoyoshi, Hiroshi Kawashimo, Daisuke Nishimura, Kazuhiko Nakao, Keisuke Hamasaki, Mariko Fukuta, Koichiro Kusumoto, Takashi Goto |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular Antineoplastic Agents Gastroenterology Cohort Studies Lesion Japan Internal medicine Hepatectomy Humans Medicine In patient Chemoembolization Therapeutic neoplasms Survival rate Aged Neoplasm Staging Ethanol Hepatology business.industry Liver Neoplasms Middle Aged medicine.disease Thrombosis digestive system diseases Survival Rate Treatment modality Hepatocellular carcinoma Cohort Solvents Main portal vein Female medicine.symptom business |
| Zdroj: | Clinical Gastroenterology and Hepatology. 4:1177-1183 |
| ISSN: | 1542-3565 |
| DOI: | 10.1016/j.cgh.2006.06.008 |
| Popis: | Background & Aims: Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. However, although the therapeutic approaches for HCC have progressed rapidly, it remains unknown whether the current management of patients with HCC has reduced its mortality. We analyzed changes of survival rate in patients with HCC over a 20-year period. Methods: Between 1982 and 2001, 463 patients were diagnosed with HCC at our hospital. Subjects were enrolled in the current cohort according to the following inclusion criteria: HCC lesion measuring less than 3 cm in diameter, no evidence of extrahepatic metastasis, and no evidence of main portal vein infiltration/thrombosis. A total of 257 patients with HCC were recruited for this study, and categorized into 5-year intervals. Results: The survival rates improved significantly during the study period. When the patients were stratified according to Child–Pugh score, only patients with Child's B showed improved survival rates. Furthermore, patients with surgical resection or transarterial chemoembolization during the latter period had a better prognosis than those during the early period. Conclusions: Our findings suggest that the development of therapeutic interventions for HCC have led to improvements in the prognosis for HCC patients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|