Antimicrobial resistance in mollicutes: known and newly emerging mechanisms
| Autor: | Olga A. Chernova, Tatiana Y Malygina, Natalia B Baranova, Alexey A. Mouzykantov, Rustam Aminov, Vladislav M. Chernov, Maxim V. Trushin, Elena S Medvedeva |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Biomedical Research biology 030106 microbiology Class Bacilli biology.organism_classification Antimicrobial Microbiology Anti-Bacterial Agents 03 medical and health sciences Antibiotic resistance Acholeplasma laidlawii Drug Resistance Bacterial Genetics Mollicutes Molecular Biology Gene Tenericutes Bacteria Antibiotic resistance genes |
| Zdroj: | FEMS Microbiology Letters. 365 |
| ISSN: | 1574-6968 |
| DOI: | 10.1093/femsle/fny185 |
| Popis: | This review is devoted to the mechanisms of antibiotic resistance in mollicutes (class Bacilli, subclass Mollicutes), the smallest self-replicating bacteria, that can cause diseases in plants, animals and humans, and also contaminate cell cultures and vaccine preparations. Research in this area has been mainly based on the ubiquitous mollicute and the main contaminant of cell cultures, Acholeplasma laidlawii. The omics technologies applied to this and other bacteria have yielded a complex picture of responses to antimicrobials, including their removal from the cell, the acquisition of antibiotic resistance genes and mutations that potentially allow global reprogramming of many cellular processes. This review provides a brief summary of well-known resistance mechanisms that have been demonstrated in several mollicutes species and, in more detail, novel mechanisms revealed in A. laidlawii, including the least explored vesicle-mediated transfer of short RNAs with a regulatory potency. We hope that this review highlights new avenues for further studies on antimicrobial resistance in these bacteria for both a basic science and an application perspective of infection control and management in clinical and research/production settings. |
| Databáze: | OpenAIRE |
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