Amyloid β influences the relationship between cortical thickness and vascular load
| Autor: | Kirsty Lu, Carole H. Sudre, David M. Cash, Thomas D. Parker, Jonathan M. Schott, Jennifer M. Nicholas, Sarah E Keuss, Ian B. Malone, Nick C. Fox, David L. Thomas, Christopher A. Lane, Sebastian J. Crutch, Sarah M Buchanan, Sarah-Naomi James, Marcus Richards, Heidi Murray-Smith, Ashvini Keshavan, Andrew Wong |
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| Rok vydání: | 2020 |
| Předmět: |
MRC National Survey of Health and Development
Pathology medicine.medical_specialty Amyloid β Amyloid Amyloid beta Neuroimaging lcsh:Geriatrics lcsh:RC346-429 medicine Pathological lcsh:Neurology. Diseases of the nervous system biology medicine.diagnostic_test business.industry Neurodegeneration neurodegeneration amyloid Alzheimer's disease cortical thickness white matter hyperintensities medicine.disease Hyperintensity lcsh:RC952-954.6 Psychiatry and Mental health Positron emission tomography biology.protein biomarker Biomarker (medicine) Neurology (clinical) business cognitively normal |
| Zdroj: | Alzheimer's & Dementia : Diagnosis, Assessment & Disease Monitoring Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, Vol 12, Iss 1, Pp n/a-n/a (2020) |
| ISSN: | 2352-8729 |
| Popis: | Introduction Cortical thickness has been proposed as a biomarker of Alzheimer's disease (AD)– related neurodegeneration, but the nature of its relationship with amyloid beta (Aβ) deposition and white matter hyperintensity volume (WMHV) in cognitively normal adults is unclear. Methods We investigated the influences of Aβ status (negative/positive) and WMHV on cortical thickness in 408 cognitively normal adults aged 69.2 to 71.9 years who underwent 18F‐Florbetapir positron emission tomography (PET) and structural magnetic resonance imaging (MRI). Two previously defined Alzheimer's disease (AD) cortical signature regions and the major cortical lobes were selected as regions of interest (ROIs) for cortical thickness. Results Higher WMHV, but not Aβ status, predicted lower cortical thickness across all participants, in all ROIs. Conversely, when Aβ‐positive participants were considered alone, higher WMHV predicted higher cortical thickness in a temporal AD‐signature region. Discussion WMHV may differentially influence cortical thickness depending on the presence or absence of Aβ, potentially reflecting different pathological mechanisms. |
| Databáze: | OpenAIRE |
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