Primary Prevention of Adverse Gastroduodenal Effects from Short-Term Use of Non-Steroidal Anti-Inflammatory Drugs by Omeprazole 20 mg in Healthy Subjects: A Randomized, Double-Blind, Placebo-Controlled Study
| Autor: | Lawrence B. Cohen, Tyralee Goo, Ariel A. Benson, Jay Desai, Carol A. Bodian, Kenneth M. Miller, Shefali Sanyal, James Aisenberg |
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| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Naproxen Physiology medicine.drug_class Placebo-controlled study Proton-pump inhibitor Pilot Projects Placebo Gastroenterology law.invention Double-Blind Method Randomized controlled trial Reference Values law Internal medicine Gastroscopy medicine Humans Stomach Ulcer Dyspepsia Adverse effect Duodenoscopy Omeprazole Aged Helicobacter pylori business.industry Anti-Inflammatory Agents Non-Steroidal Proton Pump Inhibitors Middle Aged Hepatology Surgery Treatment Outcome Duodenal Ulcer Female business medicine.drug |
| Zdroj: | Digestive Diseases and Sciences. 53:2059-2065 |
| ISSN: | 1573-2568 0163-2116 |
| DOI: | 10.1007/s10620-007-0127-4 |
| Popis: | The effectiveness of low-dose omeprazole as primary prevention of gastrointestinal adverse events due to episodic use of non-selective NSAIDs was evaluated. Healthy adults aged 50–75 who did not take chronic NSAIDs were randomized to a 6.5-day treatment of naproxen 500 mg twice daily plus omeprazole 20 mg daily or naproxen 500 mg twice daily plus placebo. Seventy subjects were enrolled (mean age 58.6 years, proportion >60 = 41.4%). Subjects receiving naproxen plus omeprazole developed fewer gastroduodenal ulcers compared to subjects receiving naproxen plus placebo (11.8% vs. 46.9%, P = 0.002). Likewise, naproxen plus omeprazole was associated with a decreased risk of ulceration and/or >5 erosions (38.2% vs. 81.3%, P ≤ 0.001), and a smaller change in dyspepsia score. Considering their relatively low cost, ready availability, and favorable safety profile, low-dose PPI co-prescription in healthy adults requiring short-term therapy with non-selective NSAIDs may be reasonable. |
| Databáze: | OpenAIRE |
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