Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology

Autor:	Tamás Takács, Anita Kurilla, Gyöngyi Kudlik, László Buday, Loretta László, Virág Vas, Kitti Koprivanacz
Rok vydání:	2021
Předmět:	Proto-Oncogene Proteins B-raf cancer stem cells 0301 basic medicine Colorectal cancer colorectal cancer Review Biology medicine.disease_cause Metastasis Proto-Oncogene Proteins p21(ras) 03 medical and health sciences 0302 clinical medicine RAS signalling Cancer stem cell KRAS RAS-driven metastasis medicine Humans Young adult lcsh:QH301-705.5 neoplasms Cancer General Medicine medicine.disease digestive system diseases Gene Expression Regulation Neoplastic 030104 developmental biology lcsh:Biology (General) CRC with age 030220 oncology & carcinogenesis Mutation Cancer research Colorectal Neoplasms
Zdroj:	Cells, Vol 10, Iss 667, p 667 (2021) Cells
ISSN:	2073-4409
DOI:	10.3390/cells10030667
Popis:	The most commonly mutated isoform of RAS among all cancer subtypes is KRAS. In this review, we focus on the special role of KRAS mutations in colorectal cancer (CRC), aiming to collect recent data on KRAS-driven enhanced cell signalling, in vitro and in vivo research models, and CRC development-related processes such as metastasis and cancer stem cell formation. We attempt to cover the diverse nature of the effects of KRAS mutations on age-related CRC development. As the incidence of CRC is rising in young adults, we have reviewed the driving forces of ageing-dependent CRC.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b54e4aaa874b1cc61393b9e35c769a5c https://doi.org/10.3390/cells10030667 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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