Variation of Resistin Gene Is Correlated with Insulin Resistance in Obese People of Indonesia
| Autor: | Rizki Fajar Utami, Pramudji Hastuti, Meirlin Rambu Kaita Riwa, Tasmini Tasmini, Steven Steven, Ahmad Hamim Sadewa |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
obesity medicine.medical_treatment Population lcsh:Medicine 030209 endocrinology & metabolism polymorphism 03 medical and health sciences 0302 clinical medicine Insulin resistance Basic Science Polymorphism (computer science) Internal medicine insulin resistance Genotype medicine Blood glucose 030212 general & internal medicine Risk factor education education.field_of_study business.industry Insulin lcsh:R nutritional and metabolic diseases General Medicine medicine.disease Obesity Endocrinology Resistin resistin gene business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Open Access Macedonian Journal of Medical Sciences, Vol 7, Iss 12 (2019) Open Access Macedonian Journal of Medical Sciences; Vol 7 No 12 (2019): Jun 30 (OAMJMS); 1891-1895 Open Access Macedonian Journal of Medical Sciences |
| ISSN: | 1857-9655 |
| Popis: | BACKGROUND: Obesity is considered associated with an increase of resistin levels that plays a role in the regulation of energy and maintaining fasting blood glucose. Polymorphism of resistin is thought to be correlated with the levels of resistin and insulin resistance.AIM: This study aimed to examine the association of +299G > A and -420C > G resistin (RETN) gene with resistin level and insulin resistance in obese people of Indonesia.METHODS: We examined 142 healthy unrelated subjects consisting of 71 obese and 71 controls. Fasting blood glucose was measured by the enzymatic method while the resistin and insulin levels were measured by Elisa method. Insulin resistance was calculated by HOMA-IR index. Polymorphisms of RETN genes were examined by the Polymerase Chain Reaction-Restriction Fragment Length Polymorphism (PCR-RFLP) method, and the data was tested. The data were correlated with Kruskal Wallis continue logistic regression and simple linear regressionRESULTS: In the obese group, there was an increased level of insulin (17.74 vs 11.27 mU/L) and insulin resistance (HOMA-IR 3.9 vs 1.46) compared to the control group. Polymorphism of +299G > A was associated with insulin resistance (GA and GA + AA genotype significantly different compare GG genotype with P < 0.001). Resistin level was negatively correlated with insulin level (P = 0.017). CONCLUSION: In this study, polymorphism of +299G > A was identified as a risk factor for insulin resistance, and there was a significant association of serum resistin level with insulin level in the population of Indonesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|