Growth of desferrioxamine-deficientStreptomycesmutants through xenosiderophore piracy of airborne fungal contaminations
| Autor: | Marc Ongena, Delphine Adam, Anthony Arguelles Arias, Stéphany Lambert, Loïc Martinet, Elodie Tenconi, Sébastien Rigali, Marie-Pierre Hayette |
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| Rok vydání: | 2015 |
| Předmět: |
Siderophore
Iron Siderophores Streptomyces coelicolor Deferoxamine Biology Secondary metabolite Hydroxamic Acids Ferric Compounds Applied Microbiology and Biotechnology Microbiology Streptomyces chemistry.chemical_compound Ascomycota medicine Secondary metabolism Ferrichrome Ecology Penicillium biology.organism_classification chemistry ATP-Binding Cassette Transporters Bacteria medicine.drug |
| Zdroj: | FEMS Microbiology Ecology. 91:fiv080 |
| ISSN: | 1574-6941 |
| DOI: | 10.1093/femsec/fiv080 |
| Popis: | Due to the necessity of iron for housekeeping functions, nutrition, morphogenesis and secondary metabolite production, siderophore piracy could be a key strategy in soil and substrate colonization by microorganisms. Here we report that mutants of bacterium Streptomyces coelicolor unable to produce desferrioxamine siderophores could recover growth when the plates were contaminated by indoor air spores of a Penicillium species and Engyodontium album. UPLC-ESI-MS analysis revealed that the HPLC fractions with the extracellular 'resuscitation' factors of the Penicillium isolate were only those that contained siderophores, i.e. Fe-dimerum acid, ferrichrome, fusarinine C and coprogen. The restored growth of the Streptomyces mutants devoid of desferrioxamine is most likely mediated through xenosiderophore uptake as the cultivability depends on the gene encoding the ABC-transporter-associated DesE siderophore-binding protein. That a filamentous fungus allows the growth of desferrioxamine non-producing Streptomyces in cocultures confirms that xenosiderophore piracy plays a vital role in nutritional interactions between these taxonomically unrelated filamentous microorganisms. |
| Databáze: | OpenAIRE |
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