Quality of Life and Cosmesis after Breast Cancer: Whole Breast Radiotherapy vs Partial Breast High-dose-rate Brachytherapy
| Autor: | Elisabetta Perrucci, Manuela Margaritelli, Alessia Farneti, Valentina Lancellotta, Cynthia Aristei, Isabella Palumbo, Vittorio Bini, Lorenzo Falcinelli, Giorgia Capezzali |
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| Rok vydání: | 2015 |
| Předmět: |
Adult
Oncology Cancer Research medicine.medical_specialty Time Factors medicine.medical_treatment Brachytherapy Breast Neoplasms Mastectomy Segmental Partial breast irradiation Breast cancer Whole Breast Irradiation Surveys and Questionnaires Internal medicine Body Image medicine Humans Aged Neoplasm Staging Whole breast irradiation business.industry Carcinoma Ductal Breast Cosmesis Partial Breast Irradiation Radiotherapy Dosage Fear General Medicine Middle Aged medicine.disease High-Dose Rate Brachytherapy Quality of life Radiation therapy Treatment Outcome Patient Satisfaction Quality of Life Female Radiotherapy Adjuvant Neoplasm Recurrence Local business Mastectomy |
| Zdroj: | Tumori Journal. 101:161-167 |
| ISSN: | 2038-2529 0300-8916 |
| DOI: | 10.5301/tj.5000233 |
| Popis: | Aim and Background Conservative surgery and radiotherapy for early breast cancer offers a better quality of life than mastectomy. As 80–85% of breast relapses develop close to the tumour bed, partial breast irradiation was developed to overcome drawbacks with standard radiotherapy. This study compares quality of life and cosmesis after partial breast multi-catheter high-dose rate interstitial brachytherapy or standard radiotherapy. Methods A questionnaire, exploring body image, fear of recurrence, satisfaction with treatment and cosmesis, was administered to 39 partial and 78 whole breast patients at a median of 20 and 80 months after radiotherapy. Patients' and physicians' cosmetic assessments were compared. Results Groups were well-matched, except for: a higher percentage of chemotherapy-treated patients in the whole breast group and a older median age and a higher percentage of infiltrating ductal carcinoma G1 in partial breast group. At first and second analysis no significant inter-group difference emerged on body image and fear of recurrence, while partial breast patients were more satisfied with cosmetic outcome and at first analysis with treatment. Comparing results from first and second analysis into each treatment group, body image was significantly better at the first analysis in both groups. Fear of recurrence was unchanged. No differences were found in cosmesis as assessed by patients. At first and second analyses physicians' assessment of cosmesis was significantly better in the partial breast group. Conclusions Even at longer follow-up, quality of life is similar after partial or whole breast irradiation. Cosmesis is better after partial breast irradiation. |
| Databáze: | OpenAIRE |
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