Distribution of L-tryptophan in normal and glucose ? loaded mice
| Autor: | S. Närvänen, Eeva-Liisa Sainio, Pertti Sainio, Pentti Tuohimaa |
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| Rok vydání: | 1995 |
| Předmět: |
Drug
media_common.quotation_subject Clinical Biochemistry 030209 endocrinology & metabolism macromolecular substances Pharmacology Biology Biochemistry 03 medical and health sciences 0302 clinical medicine Distribution (pharmacology) Essential amino acid 030304 developmental biology media_common chemistry.chemical_classification 0303 health sciences musculoskeletal neural and ocular physiology digestive oral and skin physiology Organic Chemistry Tryptophan 3. Good health Amino acid nervous system chemistry Food supplement Physiological actions |
| Zdroj: | Amino Acids. 8:209-216 |
| ISSN: | 1438-2199 0939-4451 |
| DOI: | 10.1007/bf00806494 |
| Popis: | L-tryptophan is an essential amino acid in food, but is also widely used as a drug on the basis of several physiological actions. Lately, tryptophan's uses as a drug and as a food supplement have been discontinued in several countries due to its severe side-effects.In the present study, the distribution of tryptophan in mice was studied with special attention on the target organs, where the drug has been shown to have pathological or physiological effects.The results showed that several organs took up tryptophan and that glucose loading increased the accumulation. An interesting finding was that the highest concentration of tryptophan was found in the pancreas. The hypophysis and adrenal glands were also sites of accumulation. Within the brain the highest accumulation was found in the cerebrum. High concentrations were also seen in the gastrointestinal tract and bone marrow.The connection between the accumulation of tryptophan and its normal and pathophysiological effects is discussed. |
| Databáze: | OpenAIRE |
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