Serum Apolipoprotein J in Health, Coronary Heart Disease and Type 2 Diabetes Mellitus
| Autor: | Masahiro Tsuji, Taro Maruyama, Motoo Tsushima, Satoshi Saito, Mitsuaki Ishihara, Hiroaki Hattori, Yoshiyuki Sasaguri, Takahiro Ueno, Jun Ishii, Irina P. Miller, Tohru Egashira, Takayuki Fujioka, Yoshikazu Miwa, Tadao Iwasaki, Takeshi Kujiraoka, Norman E. Miller |
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| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Apolipoprotein B Coronary Disease Enzyme-Linked Immunosorbent Assay Type 2 diabetes chemistry.chemical_compound Reference Values Diabetes mellitus Internal medicine Internal Medicine medicine Humans biology business.industry Cholesterol Biochemistry (medical) Paraoxonase Antibodies Monoclonal Type 2 Diabetes Mellitus Middle Aged medicine.disease PON1 Clusterin Endocrinology Diabetes Mellitus Type 2 chemistry biology.protein Cardiology Female lipids (amino acids peptides and proteins) Cardiology and Cardiovascular Medicine business Body mass index |
| Zdroj: | Journal of Atherosclerosis and Thrombosis. 13:314-322 |
| ISSN: | 1880-3873 1340-3478 |
| Popis: | Apolipoprotein (apo) J, clusterin, is ubiquitously expressed in many tissues, and is a component of high-density lipoproteins (HDLs). There is experimental evidence that it may be anti-atherogenic through its effects on cholesterol transport, smooth muscle cell proliferation and lipid peroxidation. HDLs containing apo J and apo A-I carry paraoxonase (PON1), which protects low-density lipoproteins from oxidative modification; however, the extent to which apo J affects coronary heart disease (CHD) is not known. We have developed a sandwich ELISA that enables apo J to be assayed in the range of 13-200 microg/mL. Serum apo J was 52.8+/-0.8 microg/mL (mean+/-SEM; range, 36.0-84.3 microg/mL; n=92) in healthy Japanese men, and 49.3+/-0.5 microg/mL (34.5-72.8; n=241) in healthy Japanese women. Multiple regression of these data and results from 67 men with CHD showed that apo J concentration was unrelated to age, sex or body mass index, but was positively related to serum PON1 (p |
| Databáze: | OpenAIRE |
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