Membrane-associated glucocorticoid activity Is necessary for modulation of long-term memory via chromatin modification
| Autor: | Jakob Haettig, Daniel P. Stefanko, Benno Roozendaal, Sara M. Cabrera, Roelina Hagewoud, Marcelo A. Wood, Melissa Malvaez, Angelina Hernandez |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Epigenetics in learning and memory ACETYLATION PROTEIN CBP Hippocampus Mice Transgenic Article Rats Sprague-Dawley Mice chemistry.chemical_compound Receptors Glucocorticoid Glucocorticoid receptor Memory Corticosterone SYNAPTIC PLASTICITY Animals RUBINSTEIN-TAYBI-SYNDROME Gene Knock-In Techniques INSULAR CORTEX Glucocorticoids CONSOLIDATION ADRENAL STRESS HORMONES Long-term memory General Neuroscience Cell Membrane Recognition Psychology BASOLATERAL AMYGDALA Chromatin Rats NORADRENERGIC ACTIVATION Mice Inbred C57BL chemistry OBJECT RECOGNITION MEMORY Memory consolidation Histone deacetylase Psychology Neuroscience |
| Zdroj: | The Journal of Neuroscience, 30(14), 5037-5046. Oxford University Press |
| ISSN: | 1529-2401 0270-6474 |
| Popis: | Glucocorticoid hormones enhance the consolidation of long-term memory of emotionally arousing training experiences. This memory enhancement requires activation of the cAMP-dependent kinase pathway and the subsequent phosphorylation of cAMP response-element binding (CREB) protein. Here, we demonstrate that glucocorticoids enhance the consolidation of hippocampus-dependent and hippocampus-independent aspects of object recognition memory via chromatin modification. More specifically, systemic corticosterone increases histone acetylation, a form of chromatin modification, in both the hippocampus and insular cortex following training on an object recognition task. This led us to examine whether increasing histone acetylation via histone deacetylase (HDAC) inhibition enhances memory in a manner similar to corticosterone. We found a double dissociation between posttraining HDAC inhibitor infusion into the insular cortex and hippocampus on the enhancement of object recognition and object location memory, respectively. In determining the molecular pathway upstream of glucocorticoids' effects on chromatin modification, we found that activation of membrane-associated glucocorticoid receptors (GRs) and the subsequent interaction between phospho-CREB and CREB-binding protein (CBP) appear to be necessary for glucocorticoids to enhance memory consolidation via chromatin modification. In contrast, mineralocorticoid receptors (MRs) do not appear to be involved. The findings also indicate that glucocorticoid activity has differential influences on hippocampus-dependent and hippocampus-independent components of memory for objects. |
| Databáze: | OpenAIRE |
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