Recovery from auditory and visual neglect after optokinetic stimulation with pursuit eye movements--transient modulation and enduring treatment effects
| Autor: | Stefan Reinhart, Helmut Hildebrandt, Georg Kerkhoff, C. Marquardt, Wolfram Ziegler, Ingo Keller, Frank Artinger |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
Male medicine.medical_specialty genetic structures Cognitive Neuroscience Visual space media_common.quotation_subject Statistics as Topic Experimental and Cognitive Psychology Nystagmus Audiology Neuropsychological Tests Smooth pursuit Functional Laterality Statistics Nonparametric Neglect Perceptual Disorders Behavioral Neuroscience medicine Humans Attention Nystagmus Optokinetic media_common Aged Visual search Sensory stimulation therapy Crossmodal Hearing Tests Eye movement Brain Recovery of Function Middle Aged Magnetic Resonance Imaging Acoustic Stimulation Reading Auditory Perception Visual Perception Female medicine.symptom Psychology Photic Stimulation Psychomotor Performance Cognitive psychology Follow-Up Studies |
| Zdroj: | Neuropsychologia. 50(6) |
| ISSN: | 1873-3514 |
| Popis: | Optokinetic stimulation (OKS) modulates many facets of the neglect syndrome. This sensory stimulation technique is known to activate multiple brain regions (temporo-parietal cortex, basal ganglia, brain stem, cerebellum) some of which are involved in auditory and visual space coding. Here, we evaluated whether OKS modulates auditory neglect transiently and induces a sustained effect (Study 1), and whether repetitive OKS permanently recovers auditory neglect (Study 2). In Study 1, 20 patients with visuospatial neglect and auditory neglect in an auditory midline task following rightsided stroke were randomly allocated to an experimental and a control group matched for neglect severity and socio-demographic factors. Both groups showed a stable, pathological shift of their auditory subjective median plane (ASMP) in front space to the right side. During leftward OKS the experimental group showed a complete normalization of the shift of the ASMP, which endured until 30 min poststimulation, and returned almost to baseline values 24h after OKS. In contrast, the control group who viewed the identical but static dot pattern, showed neither change in their ASMP during this condition, nor any significant change at 30 min or 24h poststimulation. In Study 2, we show in two samples of neglect patients (N = 3 each) that repetitive leftward OKS with smooth pursuit eye movements as a therapy induces lasting improvements in auditory (the ASMP) and visual neglect while visual scanning therapy yielded no measurable effects on auditory and significantly smaller effects on visual neglect. In conclusion, the experiments show that a single session of OKS induces rapid though transient recovery from auditory neglect including a sustained effect after termination of stimulation, while repetitive OKS therapy yields enduring and multimodal recovery from auditory and visual neglect. OKS therapy with pursuit eye movements therefore represents a multimodally effective and easily applicable technique for the treatment of auditory and visual neglect. |
| Databáze: | OpenAIRE |
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