Standardized low-resolution brain electromagnetic tomography (sLORETA) in the prediction of response to cholinesterase inhibitors in patients with Alzheimer's disease
| Autor: | Frantiska Diblikova, Milos Matousek, Ales Bartos, Martin Brunovsky, Vladimir Krajca, Lucie Zavesicka |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Rivastigmine
medicine.medical_specialty biology lcsh:RC435-571 Low resolution Disease behavioral disciplines and activities Psychiatry and Mental health lcsh:Psychiatry mental disorders biology.protein medicine Galantamine In patient Psychiatry Donepezil Psychology Resting eeg Cholinesterase medicine.drug |
| Zdroj: | Annals of General Psychiatry, Vol 7, Iss Suppl 1, p S277 (2008) |
| ISSN: | 1744-859X |
| DOI: | 10.1186/1744-859x-7-s1-s277 |
| Popis: | Materials and methods Resting EEG was recorded in 20 mild to moderate AD patients (mean age= 75.04 years; 13 women and 7 men; MMSE 15-24) before and after 6 months and 2 years on ChEI (donepezil, rivastigmine, galantamine) treatment. Based on changes of MMSE scores after 2 years follow-up, 11 patients were classified as Non-responders (decrease of MMSE > 2) and 9 patients as Responders (decrease of MMSE < 2). The localization of the differences in activity between two groups (at baseline) and within groups (baseline vs. 6 months) was assessed by voxel-by-voxel ttests of the sLORETA images of the log-transformed computed current density power in seven frequency bands. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|