Methadone in the Treatment of Neuropathic Pain
Autor: | Gil Schreier, Abdulaziz Al-Mahrezi, Bruno Gagnon |
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Rok vydání: | 2003 |
Předmět: |
Adult
Male endocrine system diseases medicine.drug_class Pain ladder medicine Humans Aged Pain Measurement Aged 80 and over lcsh:R5-920 business.industry Mononeuropathies nutritional and metabolic diseases Middle Aged Receptor antagonist Pain Intractable Anesthesiology and Pain Medicine Neurology Anesthesia Neuropathic pain Female lcsh:Medicine (General) business Cancer pain Methadone hormones hormone substitutes and hormone antagonists medicine.drug |
Zdroj: | Pain Research and Management, Vol 8, Iss 3, Pp 149-154 (2003) |
ISSN: | 1203-6765 |
DOI: | 10.1155/2003/236718 |
Popis: | BACKGROUND: Methadone, being an N-Methyl-D-Aspartate receptor antagonist, may have a potential role in the treatment of neuropathic pain.OBJECTIVES: To evaluate the effect of methadone in the treatment of neuropathic pain and to estimate the possible dose ranges needed for pain control.METHODS: Methadone was offered as a treatment option to consecutive cancer and noncancer patients with neuropathic pain. Pain intensity was measured by the visual analogue scale (VAS) (0-10 cm where 0 = no pain and 10 = worst possible pain). Mechanical allodynia and paroxysmal (shooting) pain were assessed clinically. All assessments were collected prospectively before treatment and once a stable dose of methadone was reached.RESULTS: A total number of 18 patients met our inclusion criteria. The mean pretreatment VAS ± SD was 7.7±1.5 cm and this dropped significantly to 1.4±1.7 cm on a stable dose of methadone (PCONCLUSION: Methadone at relatively low doses seems to be useful in the treatment of neuropathic pain. |
Databáze: | OpenAIRE |
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