Graph theory analysis of the dopamine D2 receptor network in Parkinson's disease patients with cognitive decline
| Autor: | Mikaeel Valli, Leigh Christopher, Ariel Graff-Guerrero, Antonio P. Strafella, Alexander Mihaescu, Yuko Koshimori, María Díez-Cirarda, Jinhee Kim, Sang Soo Cho, Mario Masellis |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Male Parkinson's disease Dopamine Partial volume Neuropsychological Tests 03 medical and health sciences Cellular and Molecular Neuroscience 0302 clinical medicine Dopamine receptor D2 Medicine Humans Cognitive Dysfunction Cognitive decline Aged Brain Mapping business.industry Receptors Dopamine D2 Montreal Cognitive Assessment Binding potential Brain Cognition Parkinson Disease Middle Aged medicine.disease 030104 developmental biology Positron-Emission Tomography Female Nerve Net business Neuroscience 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of neuroscience researchREFERENCES. 99(3) |
| ISSN: | 1097-4547 |
| Popis: | Cognitive decline in Parkinson's disease (PD) is a common sequela of the disorder that has a large impact on patient well-being. Its physiological etiology, however, remains elusive. Our study used graph theory analysis to investigate the large-scale topological patterns of the extrastriatal dopamine D2 receptor network. We used positron emission tomography with [11 C]FLB-457 to measure the binding potential of cortical dopamine D2 receptors in two networks: the meso-cortical dopamine network and the meso-limbic dopamine network. We also investigated the application of partial volume effect correction (PVEC) in conjunction with graph theory analysis. Three groups were investigated in this study divided according to their cognitive status as measured by the Montreal Cognitive Assessment score, with a score ≤25 considered cognitively impaired: (a) healthy controls (n = 13, 11 female), (b) cognitively unimpaired PD patients (PD-CU, n = 13, 5 female), and (c) PD patients with mild cognitive impairment (PD-MCI, n = 17, 4 female). In the meso-cortical network, we observed increased small-worldness, normalized clustering, and local efficiency in the PD-CU group compared to the PD-MCI group, as well as a hub shift in the PD-MCI group. Compensatory reorganization of the meso-cortical dopamine D2 receptor network may be responsible for some of the cognitive preservation observed in PD-CU. These results were found without PVEC applied and PVEC proved detrimental to the graph theory analysis. Overall, our findings demonstrate how graph theory analysis can be used to detect subtle changes in the brain that would otherwise be missed by regional comparisons of receptor density. |
| Databáze: | OpenAIRE |
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