Quantitative Susceptibility Mapping of the Hippocampal Fimbria in Alzheimer's Disease
| Autor: | Chun Ki Franklin Au, Wanting Liu, Ho Ko, Eric Y.L. Leung, Sirong Chen, Jill Abrigo, Chunlei Liu, Vincent Mok, Jack Y. B. Lee, Lisa Wing Chi Au, Queenie Chan, Weitian Chen, Chi-Lai Ho |
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| Rok vydání: | 2020 |
| Předmět: |
Adult
Pathology medicine.medical_specialty Fimbria Disease Biology Hippocampal formation Hippocampus 030218 nuclear medicine & medical imaging White matter 03 medical and health sciences 0302 clinical medicine Alzheimer Disease medicine Humans Radiology Nuclear Medicine and imaging Hippocampal fimbria Gray Matter Retrospective Studies Brain Mapping Receiver operating characteristic Quantitative susceptibility mapping Magnetic Resonance Imaging medicine.anatomical_structure Cross-Sectional Studies Analysis of variance |
| Zdroj: | Journal of magnetic resonance imaging : JMRIREFERENCES. 53(6) |
| ISSN: | 1522-2586 |
| Popis: | Background The fimbria is a small white matter bundle that connects the hippocampus to the rest of the brain. Damage to the hippocampal gray matter is established in Alzheimer's disease (AD), but the hippocampal fimbrial status in the pathogenesis of AD is unclear. AD-related demyelination and iron deposition alter the diamagnetic and paramagnetic composition of tissues, which can be measured by quantitative susceptibility mapping (QSM). Hypothesis AD is associated with microstructural changes in the fimbria that might be detected by QSM. Study type Retrospective cross-sectional study. Subjects In all, 53 adults comprised of controls (n = 30), subjects with early stage AD (n = 13), and late stage AD (n = 10) who were classified according to their amyloid and tau status and presence of hippocampal atrophy. Field strength / sequence 3T; 3D fast-field echo sequence for QSM analysis and 3D T1 -weighted MP-RAGE sequence for anatomical analysis. Assessment Segmentation of the left hippocampal fimbria subfield was performed on T1 -weighted images and was applied to the coregistered QSM map for extraction of the mean, median, minimum, and maximum values of QSM. Statistical tests Group comparison of QSM values using analysis of variance (ANOVA) with post-hoc Tukey's test, accuracy of binary differentiation using receiver operating characteristic (ROC), and individual classification using discriminant analysis. Results QSMmean and QSMmedian values were significantly different among the three groups (P Data conclusion The fimbria showed higher magnetic susceptibility in AD compared with controls. Level of evidence 2 TECHNICAL EFFICACY STAGE: 3. |
| Databáze: | OpenAIRE |
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