Intake of Ultra-processed Foods Is Associated with an Increased Risk of Crohn’s Disease: A Cross-sectional and Prospective Analysis of 187 154 Participants in the UK Biobank

Autor: Jie Chen, Judith Wellens, Rahul Kalla, Tian Fu, Minzi Deng, Han Zhang, Shuai Yuan, Xiaoyan Wang, Evropi Theodoratou, Xue Li, Jack Satsangi
Rok vydání: 2022
Předmět:
Zdroj: Chen, J, Wellens, J, Kalla, R, Fu, T, Deng, M, Zhang, H, Yuan, S, Wang, X, Theodoratou, E, Li, X & Satsangi, J 2022, ' Intake of ultra-processed foods is associated with an increased risk of Crohn's disease : a cross-sectional and prospective analysis of 187,154 participants in the UK Biobank ', Journal of Crohn's and Colitis . https://doi.org/10.1093/ecco-jcc/jjac167
ISSN: 1876-4479
1873-9946
DOI: 10.1093/ecco-jcc/jjac167
Popis: Background and Aims Ultra-processed food [UPF] consumption has been linked to globally increasing incidence and prevalence of chronic diseases, including inflammatory bowel diseases [IBD]. We aimed to investigate the association between UPF consumption and IBD incidence, prevalence, and IBD-relevant outcomes. Methods We performed a cross-sectional and prospective cohort study in 187 854 individuals included in the national UK Biobank, using 24-h dietary recall questionnaires. Multivariable logistic regression and Cox proportional hazard regression were used to examine the association between UPFs and the prevalence and incidence risk of IBD, respectively. Results A total of 185 849 participants with a mean age of 56.2 were included, with a mean follow-up of 9.84 years. During follow-up, 841 developed IBD (251 Crohn’s disease [CD], and 590 ulcerative colitis [UC]). UPF intake in IBD patients was significantly higher: CD: odds ratio [OR] 1.94 (95% confidence interval [CI]: 1.52, 2.49, p Conclusion Higher intake of UPFs was associated with higher incidence of CD, but not UC. In individuals with a pre-existing diagnosis of IBD, consumption of UPFs was significantly higher compared with controls, and was associated with an increased need for IBD-related surgery. Further studies are needed to address the impact of UPF intake on disease pathogenesis and outcomes.
Databáze: OpenAIRE
Externí odkaz: